Sort   by:  
 Page size 
TranscriptomicsPAR-CLIP analysis of YTHDC1, SRSF1, SRSF3, SRSF7, SRSF9 and SRSF10 in human HeLa cells
Label the cells overexpressed Flag tagged YTHDC1, SRSF1, SRSF3, SRSF7, SRSF9 and SRSF10 with 4-SU, the RNA bound by YTHDC1 and SRSF proteins can be got by Flag IP followed by RNA isolation by using the TRIzol (Invitrogen) reagent by following the company manual.the RNA was then used for library prep...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-71096 | biostudies-arrayexpress
TranscriptomicsTranscriptomics analysis of gene expression in normal and YTHDC1, SRSF1, SRSF3, SRSF7, SRSF9 or SRSF10 deficient human HeLa cells
RNA was isolated from and YTHDC1, SRSF1, SRSF3, SRSF7, SRSF9 and SRSF10 deficient human HeLa cells using the TRIzol (Invitrogen) reagent by following the company manual. For all samples the RNA integrity was checked using an Agilent Bioanalyzer 2100. All samples showed a RIN (RNA integrity number) o...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-71095 | biostudies-arrayexpress
ProteomicsMS-based characterization of YTHDC1 interactome
Heat shock induces a cell response leading to profound changes in genome expression. Recently, N6-methyladenosine (m6A) RNA modification has been implicated in this response, but with limited information of its role in the heat-induced reprograming of gene expression. Most of m6A molecular and cellu...
ORGANISM(S): Homo sapiens (Human) 
2023-01-11 | PXD037414 | Pride
Human Nuclear m6a reader Ythdc1 Nanolc-ms/ms Interactome 
ProteomicsYTHDC1 functions as a molecular chaperone to suppress ALS-Linked hnRNPA1 mutants from aggregation
Proteostasis failure underlies many neurodegenerative disorders (NDs), yet ATP-independent chaperone mechanisms in NDs remain incompletely defined. Here, we identify the N6-methyladenosine (m6A) binding protein YTHDC1 as an ATP-independent molecular chaperone whose activity is mediated by a highly a...
ORGANISM(S): Homo sapiens (Human) 
2026-08-22 | PXD073825 | Pride
Hek293t Ythdc1δd/e Ythdc1 Lc-ms/ms 
ProteomicsYTHDC1 functions as a molecular chaperone to suppress ALS-Linked hnRNPA1 mutants from aggregation
Proteostasis failure underlies many neurodegenerative disorders (NDs), yet ATP-independent chaperone mechanisms in NDs remain incompletely defined. Here, we identify the N6-methyladenosine (m6A) binding protein YTHDC1 as an ATP-independent molecular chaperone whose activity is mediated by a highly a...
ORGANISM(S): Homo sapiens (Human) 
2026-08-22 | PXD073870 | Pride
Phosphoproteomics Ythdc1 Hnrnpa1 Hek293t Sy5y Lc-ms/ms 
ProteomicsXIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1
X-linked inhibitor of apoptosis protein (XIAP), a member of the IAP family, is overexpressed in a variety of tumors and plays an important role in tumor progression. Increasing evidence suggests that XIAP promotes metastasis of bladder cancer but the underlying mechanism is not very clear. The RNA N...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055868 | Pride
Bladder cancer invasion/ubiquitylation/xiap/ythdc1/mmp-2 
TranscriptomicsRNA sequencing analyses of human liver cancer cell line HepG2 treated with control shRNA and YTHDC1 knockdown shRNA
YTHDC1 is one of m6A reader proteins exerting multifaceted effects on determining the fate of m6A RNA within the nucleus.To understand how YTHDC1 contributes to liver cancer progression, we conducted RNA-seq assay in shCtrl and shDC1 HepG2 cells and aimed to identified YTHDC1-responsive genes.
ORGANISM(S): Homo sapiens 
2025-03-25 | E-MTAB-14193 | biostudies-arrayexpress
GenomicsThe effects of YTHDC1 on liver function [YTHDC1 HKO]
The effects of YTHDC1 on liver function [YTHDC1 HKO]
PRJNA943504 | ENA
TranscriptomicsStructural basis of YTH domain as m6A reader
The N6-methyladenosine (m6A) is the most abundant internal modification in almost all eukaryotic messenger RNAs, and is dynamically regulated. Therefore, identification of m6A readers is especially important in determining the cellular function of m6A. YTHDF2 has recently been characterized as the f...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-58352 | biostudies-arrayexpress
GenomicsYTHDC1-Hyper tribe uncover YTHDC1 binding sites in human leukemia cells
YTHDC1-Hyper tribe uncover YTHDC1 binding sites in human leukemia cells
PRJNA708310 | ENA
Sort   by:  
 Page size