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MetabolomicsDiagnostic metabolite biomarkers of chronic typhoid carriage
Background: Salmonella Typhi and Salmonella Paratyphi A are the agents of enteric (typhoid) fever; both can establish chronic carriage in the gallbladder. Chronic Salmonella carriers are typically asymptomatic, intermittently shedding bacteria in the feces, and contributing to disease transmission. ...
2018-01-17 | MTBLS579 | MetaboLights
TranscriptomicsYeast drug resistance gene mutants in glucose or ammonium limited chemostats
Homozygous deletion mutants of drug resistance genes QDR3 and PDR3 and the homozygous deletion of HO (control) were grown in ammonium limited or glucose limited synthetic defined medium in aerated, pH controlled chemostats at a dilution rate of 0.1hr-1. Samples were collected at steady state.
ORGANISM(S): Saccharomyces cerevisiae 
2013-10-23 | E-MTAB-707 | biostudies-arrayexpress
ProteomicsThe OGT TPR Interactome defined by BioID
BioID performed in HeLa cells for the TPR domain of The O-GlcNAc Transferase and eGFP (negative control). Used to determine TPR interactors and the TPR interactome in HeLa cells. Three biological replicates were performed, with each replicate having an experimental (TPR-BirA*) and negative (eGFP-Bir...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-06-24 | MSV000085626 | MassIVE
ProteomicsSystemic remodeling of translation efficiencies on oxygen stimulus.
Protein concentrations evolve under greater evolutionary constraint than mRNA levels. In addition, translation efficiency of mRNA populations represents the chief determinant of basal protein concentrations. This raises a fundamental question as to how mRNA and protein levels are actively coordina...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079962 | MassIVE
TranscriptomicsTranscriptome analysis reveals differential splicing events in IPF lung tissue
Objectives: Idiopathic pulmonary fibrosis (IPF) is a complex disease in which a multitude of proteins and networks are disrupted. Interrogation of genome-wide transcription through RNA sequencing (RNA-Seq) enables the determination of genes whose differential expression is most significant in IPF, a...
ORGANISM(S): Homo sapiens 
2014-03-27 | E-GEOD-52463 | biostudies-arrayexpress
ProteomicsOxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B
The eukaryotic translation initiation factor 5B (eIF5B) is a homolog of the ancient IF2, a translation factor that facilitates initiator methionine-tRNAiMet (met-tRNAiMet) delivery to ribosomes in prokaryotes. IF2 evolved during early anaerobic cellular life and can be traced back to the last univer...
ORGANISM(S): Homo sapiens (Human) 
2018-01-03 | PXD006799 | Pride
Eif5b Oxygen Evolution Hypoxia Matrix Carbon metabolism If2 Translation 
ProteomicsSystemic remodeling of translation efficiencies on oxygen stimulus.
Protein concentrations evolve under greater evolutionary constraint than mRNA levels. In addition, translation efficiency of mRNA populations represents the chief determinant of basal protein concentrations. This raises a fundamental question as to how mRNA and protein levels are actively coordina...
ORGANISM(S): Homo sapiens (Human) 
2016-02-05 | PXD003037 | Pride
Cancer Silac Hypoxia Eif4e2 Translation Rna sequencing Eif4e 
TranscriptomicsThe Oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs [miRNA-seq].
Using high throughput sequencing of Drosophila head RNA, a small set of miRNAs that undergo robust circadian oscillations in levels were discovered. We concentrated on a cluster of six miRNAs, mir-959-964, all of which peak at about ZT12 or lights-off. The data indicate that the cluster pri-miRNA is...
ORGANISM(S): Drosophila melanogaster 
2012-11-02 | E-GEOD-40943 | biostudies-arrayexpress
UnknownMyc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma.
Not available
S-EPMC5010492 | biostudies-literature
UnknownMolecular Modeling and Functional Analysis of Exome Sequencing-Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma.
Not available
S-EPMC6369924 | biostudies-literature
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