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TranscriptomicsGlobal transcriptional profiles of WT and HOIL-1L-/- BMDMs in response to LPS and TNFa
HOIL-1L is an essential member of the linear ubiquitin assembly complex (LUBAC), which targets Nemo for linear ubiquitination during NF-kB activation in response to a variety of simuli, including LPS and TNFa treatment. HOIL-1L has also been suggested to function as a transcription factor. Here we a...
ORGANISM(S): Mus musculus 
2014-05-15 | E-GEOD-57180 | biostudies-arrayexpress
ProteomicsPathogenic phosphorylation of linear ubiquitin machinery causes inflammasome sensor degradation [Mouse]
Mass spectrometry analysis of phosphorylated sites in mouse HOIL-1L modified by PknG upon Mtb infection in iBMDMs.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-08 | PXD064141 | Pride
Mycobacterium tuberculosis Hoil-1l Pkng 
TranscriptomicsGlobal transcriptional profiles of WT and HOIL-1L-/- BMDMs in response to LPS and TNFa
HOIL-1L is an essential member of the linear ubiquitin assembly complex (LUBAC), which targets Nemo for linear ubiquitination during NF-kB activation in response to a variety of simuli, including LPS and TNFa treatment. HOIL-1L has also been suggested to function as a transcription factor. Here we a...
ORGANISM(S): Mus musculus 
2014-05-15 | GSE57180 | GEO
ProteomicsPathogenic phosphorylation of linear ubiquitin machinery causes inflammasome sensor degradation [Human]
Mass spectrometry for analysis of phosphorylation sites in human HOIL-1L modified by Mycobacterium tuberculosis PknG.
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD046319 | Pride
Pkng Mycobacterium tuberculosis Hoil-1l Nlrp3 inflammasome Lubac 
UnknownThe ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains.
Not available
S-EPMC8561004 | biostudies-literature
UnknownAttenuation of HOIL-1L ligase activity promotes systemic autoimmune disorders by augmenting linear ubiquitin signaling.
Not available
S-EPMC10967397 | biostudies-literature
UnknownHOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes.
Not available
S-EPMC11024103 | biostudies-literature
UnknownMechanistic insights into the enzymatic activity of E3 ligase HOIL-1L and its regulation by the linear ubiquitin chain binding.
Not available
S-EPMC10575588 | biostudies-literature
TranscriptomicsHIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury
Exposure to hypoxia requires adaptive mechanisms for survival. During acute hypoxia, Na,K-ATPase endocytosis in alveolar epithelial cells (AEC) occurs via protein kinase C zeta (PKCζ) phosphorylation of α1- Na,K-ATPase independently of the hypoxia inducible factor (HIF). However, exaggerated Na,K-AT...
ORGANISM(S): Mus musculus 
2018-02-14 | GSE102107 | GEO
UnknownSolution structure of the HOIL-1L NZF domain reveals a conformational switch regulating linear ubiquitin affinity.
Not available
S-EPMC10511788 | biostudies-literature
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