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TranscriptomicsTranscription profiling of wild type vs wild type yeast with controls spiked in different ratios; 1:1, 1:2 and 1:10 respectively
Wild type versus wildtype Saccharomyces cerevisiae experiment with controls spiked in different ratios; 1:1, 1:2 and 1:10 respectively
ORGANISM(S): Saccharomyces cerevisiae 
2003-04-01 | E-UMCU-1 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HUVEC (Human Umbilical Vein Endothelial Cells) cells exposed to heat shock (42 degrees Celcius) for different time points (1hr, 3 hrs, 6 hr and 12 hrs) and vs non heat-shock cells with varying amounts of external spikes added
HUVEC (Human Umbilical Vein Endothelial Cells) cells were exposed to heat shock (42 degrees Celcius) for different time points (1hr, 3 hrs, 6 hr and 12 hrs) and compared to non heat-shock cells. External normalization controls were added in equal amounts to equivalent amounts of total RNA.
ORGANISM(S): Homo sapiens 
2003-04-01 | E-UMCU-2 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast cells grown into stationary phase compared with exponential mid-log grown cells including a dye-swap
S. cerevisiae cells grown into stationary phase were compared with exponential mid-log grown cells including a dye-swap. External normalization controls were added in equal amounts to equivalent amounts of total RNA.
ORGANISM(S): Saccharomyces cerevisiae 
2003-04-01 | E-UMCU-4 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of MCF7 (human mammary gland adenocarcinoma) cells deprived of serum for 30 hrs and vs non-deprived cells to test spike based normalization
MCF7 (human mammary gland adenocarcinoma) cells were deprived of serum for 30 hrs and were compared to non-deprived cells. External normalization controls were added in equal amounts to equivalent amounts of total RNA.
ORGANISM(S): Homo sapiens 
2003-04-01 | E-UMCU-3 | biostudies-arrayexpress
TranscriptomicsComparison of lymph node negative (N0) and lymph node metastasis (N+) head and neck squamous-cell carcinomas (HNSCC)
A classifier was build on 82 training samples to differentiate between lymph node negative (N0) and lymph node metastasis (N+) head and neck squamous-cell carcinomas (HNSCC). The 102 predictor genes that resulted from this classifier where then validated against a independent validation set.
ORGANISM(S): Homo sapiens 
2005-01-09 | E-UMCU-11 | biostudies-arrayexpress
TranscriptomicsJeB001: Elucidation of the distal convoluted tubule transcriptome identified new candidate players in magnesium balance
The distal convoluted tubule (DCT) plays a key role in the fine-tuning of renal Mg2+ reabsorption. In recent years, hereditary magnesium (Mg2+) transport disorders have helped to identify important players in DCT Mg2+ homeostasis. Here, we report the Mg2+-sensitive transcriptional expression of the ...
ORGANISM(S): Mus musculus 
2013-12-13 | E-GEOD-40208 | biostudies-arrayexpress
TranscriptomicsExpression profiles of the NuB4/HAT-B complex and histone knockouts
Dynamic modification of histone proteins plays a key role in regulating gene expression. However, histones themselves can also be dynamic, which potentially affects the stability of histone modifications. To determine the molecular mechanisms of histone turnover we developed a parallel screening met...
ORGANISM(S): Saccharomyces cerevisiae 
2012-05-14 | E-GEOD-30168 | biostudies-arrayexpress
TranscriptomicsMH003A:FOXO3 in control of circadian rhythms via direct regulation of Clock. Part 1: overexpression of FoxO6
Circadian rhythms are responsive to a variety of external cues, light and metabolism being the most important. In mammals, the light signal is sensed by the retina and transmitted to the SCN master clock, where it is translated into the molecular oscillator via regulation of clock gene transcription...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-41554 | biostudies-arrayexpress
TranscriptomicsMH003B:FOXO3 in control of circadian rhythms via direct regulation of Clock. Part 2: knockdown of FoxO3.
Circadian rhythms are responsive to a variety of external cues, light and metabolism being the most important. In mammals, the light signal is sensed by the retina and transmitted to the SCN master clock, where it is translated into the molecular oscillator via regulation of clock gene transcription...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-41555 | biostudies-arrayexpress
TranscriptomicsGene deletion expression profiles of yeast chromatin modifiers
Packaging of DNA into chromatin has a profound impact on gene expression. To understand how changes in chromatin influence transcription, we analyzed 165 mutants of chromatin machinery components in Saccharomyces cerevisiae. mRNA expression patterns change in 80% of mutants, always with specific eff...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-23 | E-GEOD-25909 | biostudies-arrayexpress
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