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ProteomicsDecoding Post-Translational Modification Patterns to Gain Functional Insights into Pathogenic Missense Variants
Genome sequencing has uncovered numerous pathogenic missense variants; however, their functional consequences remain largely unexplored, limiting our understanding of their precise roles in diseases. These variants may disrupt post-translational modifications (PTMs), which are crucial for cellular s...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD059468 | Pride
Machine learning Ptm 
ProteomicsDAPK3 modulates migration and invasion of triple negative breast cancers
A mass spectrometry (MS)-based kinase inhibitor pulldown assay (KIPA) was applied to analyze 16 patient-derived xenografts (PDXs) leading to the discovery that Death-Associated Protein Kinase 3 (DAPK3) is significantly and specifically overexpressed in triple negative breast cancer (TNBC). Validatio...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049187 | Pride
Luzp1 Emt Breast cancer Cancer Dapk3 Pdx 
ProteomicsCOOKIE-Pro: Covalent Inhibitor Binding Kinetics Profiling on the Proteome Scale
COOKIE-Pro mass spec dataset collected from Orbitrap Lumos for spebrutinib SB2 (20231129_Speb_SB2_TMT18_ScaleUp_MS2_8ul.mzML; Ascend_VQneo_ES75500_SP2_X.mzML) and ibrutinib IB-C8-DTB (Lang_HFL_IB_COOKIE_X). Two-point COOKIE-Pro data are collected form Orbitrap Ascend, named as "Ascend_VQneo_ES75500...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095804 | MassIVE
UnknownEnhancing cognitive performance prediction by white matter hyperintensity connectivity assessment.
Not available
S-EPMC11629703 | biostudies-literature
UnknownThe landscape of viral associations in human cancers.
Not available
S-EPMC8076016 | biostudies-literature
UnknownDivergent mutational processes distinguish hypoxic and normoxic tumours.
Not available
S-EPMC7002770 | biostudies-literature
UnknownComprehensive molecular characterization of mitochondrial genomes in human cancers.
Not available
S-EPMC7058535 | biostudies-literature
UnknownPan-cancer analysis of whole genomes.
Not available
S-EPMC7025898 | biostudies-literature
UnknownReconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig.
Not available
S-EPMC7002414 | biostudies-literature
UnknownInferring structural variant cancer cell fraction.
Not available
S-EPMC7002525 | biostudies-literature
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