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Proteomicsprotein turnover during homeostatic plasticity
Using quantitative proteomics we identified group of synaptic genes with decreased protein synthesis during homeostatic plasticity. To obtain further information about their mRNA levels/sequences (3’UTR) we performed polyA RNAseq. Using EISA analysis of Ribominus RNAseq dataset we could further diff...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-04-05 | PXD004150 | Pride
Neuron silac homeostatic plasticity 
GenomicsAstrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus
Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus
PRJNA678677 | ENA
ProteomicsNascent Proteome Remodeling following Homeostatic Scaling at Hippocampal Synapses.
Neuronal networks are subject to fluctuations in both the magnitude and frequency of inputs, requiring plasticity mechanisms to stabilize network activity. Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of neuronal connections up or down in response to large ...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-12-22 | PXD004889 | Pride
Synaptic plasticity Q exactive plus Homeostatic scaling Lfq 
UnknownMicroRNA regulation of homeostatic synaptic plasticity.
Not available
S-EPMC3136313 | biostudies-literature
ProteomicsTranscriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity
Understanding the mechanisms of synaptic plasticity is crucial for elucidating how the brain adapts to internal and external stimuli. A key objective of plasticity is maintaining physiological activity states during perturbations by adjusting synaptic transmission through negative feedback mechanism...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD056794 | Pride
Transcriptome Proteomics Organotypic tissue culture Homeostatic synaptic plasticity 
Proteomicscompartmentalized protein expression in rat hippocampal neurons undergoing homeostatic plasticity
Synaptic scaling is a form of homeostatic plasticity which allows neurons to adjust their action potential firing rate in response to chronic alterations in neural activity. Synaptic scaling requires profound changes in gene expression, but the relative contribution of local and cell-wide mechanisms...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-07-09 | PXD020745 | Pride
Neurons Stimulation Homeostatic plasticity Hippocampus Rat Cellculture Ptx Dendrites 
GenomicsAntiepileptic medication induces homeostatic synaptic plasticity in pyramidal neurons of the adult human neocortex
Antiepileptic medication induces homeostatic synaptic plasticity in pyramidal neurons of the adult human neocortex
PRJNA1021222 | ENA
GenomicsDenervated mouse CA1 pyramidal neurons express homeostatic synaptic plasticity following entorhinal cortex lesion
Denervated mouse CA1 pyramidal neurons express homeostatic synaptic plasticity following entorhinal cortex lesion
PRJNA924823 | ENA
TranscriptomicsHistone methylation by the Kleefstra Syndrome protein EHMT1 mediates homeostatic synaptic scaling.
Homeostatic plasticity, a form of synaptic plasticity, maintains the fine balance between overall excitation and inhibition in developing and mature neuronal networks. Although the synaptic mechanisms of homeostatic plasticity are well characterized, the associated transcriptional program remains po...
ORGANISM(S): Rattus norvegicus 
2016-06-30 | E-GEOD-68960 | biostudies-arrayexpress
ProteomicsPhosphorylation in synaptic plasticity
Homeostatic synaptic scaling is a compensatory mechanism that allows adjustment of the strength of synaptic connections up or down in response to changes in input to maintain global network stability. To characterize the molecular changes on the level of protein modification that contribute to synap...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-08-12 | PXD021834 | Pride
Phosphoproteomics Synaptic plasticity Bicuculline Neurons Tetrodotoxin Homeostatic scaling 
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