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ProteomicsProtein citrullination and homocitrullination profiling in mice using LC-MS/MS
Citrullination and homocitrullination are two post-translational modifications (PTMs) that may cause protein structural and functional changes. Although they have been linked to various biological processes and disease development, the understanding is still poor because of limitations to enrich, de...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-05 | PXD023733 | Pride
Citrullination Mouse Biotin thiol tag Homocitrullination Lc-ms/ms 
ProteomicsDevelopment of Motif-Specific Monoclonal Antibodies for Global Protein Citrullination Detection with Minimal Cross-Reactivity to Homocitrullination
This project focuses on developing highly specific monoclonal antibodies for detecting citrullinated proteins while minimizing cross-reactivity with homocitrullination. Citrullination, a post-translational modification catalyzed by PAD enzymes, plays key roles in immunity, inflammation, and disease....
ORGANISM(S): Homo sapiens (Human) 
2026-03-29 | PXD061971 | Pride
UnknownHomocitrullination Is a Novel Histone H1 Epigenetic Mark Dependent on Aryl Hydrocarbon Receptor Recruitment of Carbamoyl Phosphate Synthase 1.
Not available
S-EPMC4646023 | biostudies-literature
ProteomicsDevelopment of a chemoproteomic platform to identify the sites of (homo)citrullination within complex proteomes
Citrullination and homocitrullination of arginine and lysine can significantly impact protein structure and function. Citrullination of arginine is an enzymatic modification catalyzed by the Protein Arginine Deiminases (PADs). Homocitrullination of lysine is a non-enzymatic modification that occurs ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-10 | PXD069261 | Pride
Phenylglyoxal Chemoproteomics Desthiobiotin Citrulline Homocitrulline 
ProteomicsComprehensive Profiling of Rheumatoid Arthritis Antibody Repertoire
8 controls and 26 RA samples were profiled using NimbleTherapeutics high density peptide array. Array consists of >4.6M peptides, includes citrullination and homocitrullination against the entire human proteome represented as overlapping 16mer peptides.
ORGANISM(S): Homo sapiens 
2019-10-21 | GSE136052 | GEO
UnknownVaccine Can Induce CD4-Mediated Responses to Homocitrullinated Peptides via Multiple HLA-Types and Confer Anti-Tumor Immunity.
Not available
S-EPMC9028767 | biostudies-literature
GenomicsComprehensive Profiling of Rheumatoid Arthritis Antibody Repertoire
Comprehensive Profiling of Rheumatoid Arthritis Antibody Repertoire
PRJNA561136 | ENA
UnknownNovel Chimeric Peptides Based on the Enolase Peptide Antigen (CEP-1) Bearing Three Post-Translational Modifications (Citrullination, Homocitrullination and Acetylation) for Determining the Diagnosis and Severity of Rheumatoid Arthritis.
Not available
S-EPMC11477004 | biostudies-literature
UnknownModi-2 a vaccine stimulating CD4 responses to homocitrullinated self epitopes as therapy for solid cancers.
Not available
S-EPMC11603156 | biostudies-literature
UnknownA Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.
Not available
S-EPMC5860981 | biostudies-literature
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