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TranscriptomicsThe effect of homocysteine on human aortic smooth muscle cells
Vascular calcification is a common manifestation of atherosclerosis and involves cell-mediated processes similar to the formation of bone (osteogenesis). Elevated plasma levels of homocysteine are an independent risk factor for atherosclerotic vascular disease but the underlying mechanisms remain un...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-9490 | biostudies-arrayexpress
TranscriptomicsEndogenous Elevation of Homocysteine Induces Retinal Neuron Death in the Cystathionine-b-Synthase Mutant Mice
The effects of endogenous elevation of homocysteine on retinal gene expression were screened by microarray analysis, which was performed in triplicate (i.e., three different paired RNA samples) with RNA isolated from neural retinas of cbs+/- HM at 5-weeks after a methionine diet and age-matched wild...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-56458 | biostudies-arrayexpress
ProteomicsHydrogen sulfide mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small-cell lung cancer
Ferroptosis, a novel form of regulated cell death triggered by the iron-dependent peroxidation of phospholipids, offers promising penitential for cancer therapy. Hydrogen sulfide (H2S), an endogenous metabolite of the transsulfuration pathway, has been implicated in ferroptosis. However, the precise...
ORGANISM(S): Homo Sapiens 
2023-12-04 | PXD047493 |
ProteomicsStudy on biomarkers of homocysteine-induced transformation of vascular smooth muscle cells into foam cells
Objective: Foam cells, predominantly originating from vascular smooth muscle cells (VSMCs) and macrophages, are a hallmark of atherosclerotic plaque development. Strategies aimed at inhibiting foam cell formation have emerged as pivotal for atherosclerosis (AS) prevention and therapy. Homocysteine (...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD064315 | Pride
Atherosclerosis  homocysteine  biomarkers  proteomics  prm 
TranscriptomicsHomocysteine induced alterations in gene expression in neural crest cells
The amino acid homocysteine increases in the serum when there is insufficient folic acid or vitamin B12, or with certain mutations in enzymes important in methionine metabolism. Elevated homocysteine is related to increased risk for cardiovascular and other diseases in adults and elevated maternal h...
ORGANISM(S): Gallus gallus 
2007-01-26 | GSE6868 | GEO
Genomics35 somites tail single cell RNAseq in control and homocysteine treated chicken embryo
35 somites tail single cell RNAseq in control and homocysteine treated chicken embryo
PRJNA1298153 | ENA
TranscriptomicsThe effect of homocysteine on human aortic smooth muscle cells
Vascular calcification is a common manifestation of atherosclerosis and involves cell-mediated processes similar to the formation of bone (osteogenesis). Elevated plasma levels of homocysteine are an independent risk factor for atherosclerotic vascular disease but the underlying mechanisms remain un...
ORGANISM(S): Homo sapiens 
2008-10-21 | GSE9490 | GEO
ProteomicsQuantitative phosphoproteomics reveals diverse stimuli activate distinct signaling pathways during neutrophil activation
Neutrophils play an active role in acute and chronic inflammation by exhibiting functional heterogeneity. Besides beneficial role in acute infections to eliminate pathogens, neutrophils also contribute to pathogenesis of diseases associated with sterile inflammation including vascular disorders, aut...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD029046 | Pride
Infections Neutrophils Hyperglycemia Type 2 diabetes Homocysteine 
GenomicsThe effect of homocysteine on Human Aortic Endothelial Cells [RNA]
The effect of homocysteine on Human Aortic Endothelial Cells [RNA]
PRJNA733460 | ENA
GenomicsThe effect of homocysteine on Human Aortic Endothelial Cells [miRNA]
The effect of homocysteine on Human Aortic Endothelial Cells [miRNA]
PRJNA733479 | ENA
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