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ProteomicsISGylation of H2AX retains MDC1 and facilitates homologous recombination repair causing radioresistance in esophageal adenocarcinoma
High expression of interferon-stimulated gene 15 (ISG15) has been associated with poor survival in patients with esophageal adenocarcinoma (EAC). Like ubiquitin, ISG15 utilizes its C-terminal LRGG motif to post-translationally modify target proteins through a process called ISGylation, thereby influ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD071548 | Pride
Radioresistance H2ax Esophageal adenocarcinoma. Homologous recombination repair (hrr) Isgylation 
UnknownComplex Relationships Between Homologous Recombination Deficiency (HRD) Score and Mutational Status of Homologous Recombination Repair (HRR) Genes in Prostate Carcinomas.
Not available
S-EPMC12732970 | biostudies-literature
ClinicalA Study to Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes
A Phase 2, open-label, single-arm trial to evaluate the response of rucaparib in participants with various solid tumors and with deleterious mutations in Homologous Recombination Repair (HRR) genes.
2322588 | ecrin-mdr-crc
UnknownRole of Homologous Recombination Repair (HRR) Genes in Uterine Leiomyosarcomas: A Retrospective Analysis.
Not available
S-EPMC9024785 | biostudies-literature
ProteomicsUBQLN4 regulates double-strand break repair by repressing homologous recombination and is overexpressed in aggressive tumors
The ubiquitin-proteasome system (UPS) plays a crucial role in cellular homeostasis and its major role in genome stability and maintenance is rapidly emerging. Here, we identify the proteasomal shuttle factor ubiquilin-4 (UBQLN4) as a major component of the DNA damage response. We found a homozygous ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-12 | PXD011488 | Pride
Cancer Phosphorylation Dna-damage 
UnknownMutational pattern off homologous recombination repair (HRR)-related genes in upper tract urothelial carcinoma.
Not available
S-EPMC10417099 | biostudies-literature
GenomicsERα-CtBP-mediated repression of Homologous-recombination repair in ovarian cancer improves chemo-sensitivity [ChIP-seq]
ERα-CtBP-mediated repression of Homologous-recombination repair in ovarian cancer improves chemo-sensitivity [ChIP-seq]
PRJNA476785 | ENA
GenomicsERα-CtBP-mediated repression of Homologous-recombination repair in ovarian cancer improves chemo-sensitivity [RNA-seq]
ERα-CtBP-mediated repression of Homologous-recombination repair in ovarian cancer improves chemo-sensitivity [RNA-seq]
PRJNA475140 | ENA
GenomicsEMSY inhibits homologous recombination repair and the interferon response promoting lung cancer immune evasion
EMSY inhibits homologous recombination repair and the interferon response promoting lung cancer immune evasion
PRJNA739447 | ENA
UnknownRIF1 controls replication initiation and homologous recombination repair in a radiation dose-dependent manner.
Not available
S-EPMC7328141 | biostudies-literature
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