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GenomicsGenetic Analysis of Limb Malformation Disorders: Miller Syndrome Sequencing Study (LMD-MS)

The overall goal of this project is to investigate the etiology and pathogenesis of malformations (i.e., birth defects) of the limb, concentrating on abnormalities of limb patterning such as limb deficiency/duplications and multiple congenital contractures.

The exome sequences of two s...

phs000244.v1.p1 | EGA
ProteomicsMm_mESC_glyco
Mm_mESC_glyco
ORGANISM(S): Mus Musculus 
2013-12-31 | PAe003969 | PeptideAtlas
TranscriptomicsTranscription profiling of human acute myelogenous leukemia stem cells reveals disregulated gene networks
We performed the first genome-wide expression analysis directly comparing the expression profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic stem cells (LSC) from patients with acute myeloid leukemia (AML). Comparing the expression signature of normal HSC to that of L...
ORGANISM(S): Homo sapiens 
2009-08-12 | E-GEOD-17054 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A549 epithelial cells infected with polio virus or mock infected to compare Nanostring and Affymetrix technologies
Mock and poliovirus infected A549 cells were used as model system to assess Nanostring's technology for detecting mRNA transcripts, linearity of signal, reproducibility and fold change measurements. As a comparison, the same samples were measured using Affymetrix U133 2.0 plus arrays and several gen...
ORGANISM(S): Homo sapiens 
2008-02-17 | E-MEXP-1072 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model of intestinal polyposis PTEN-deficient mutant reveals intestinal stem cells initiate intestinal polyposis
Intestinal polyposis, a precancerous neoplasia, results primarily from an abnormal increase in the number of crypts. Crypts contain intestinal stem cells (ISCs). Thus intestinal polyposis provides an ideal condition for studying stem cell involvement in polyp/tumor formation. Using a conditional kno...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6078 | biostudies-arrayexpress
TranscriptomicsActivation of defense pathways in Scots pine bark after feeding by Pine Weevil (Hylobius abietis)
Coniferous trees use the oleoresin, a mixture of non-volatile non-volatile diterpene acids and a large (20-50%) volatile fraction of mono- and sesquiterpenes, as a defence tool against damaging herbivores and pathogens. Volatilization of monoterpenes increases viscosity of oleoresin and finally le...
ORGANISM(S): Pinus sylvestris 
2015-04-01 | E-GEOD-60383 | biostudies-arrayexpress
TranscriptomicsGene expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study2]
Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation We designed our time-course study (Study II) with three experimental conditions where we varied the length of time that subservient mice were exposed t...
ORGANISM(S): Mus musculus 
2013-12-04 | E-GEOD-52871 | biostudies-arrayexpress
TranscriptomicsGene expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study1]
Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation We designed our initial study (Study I) with four experimental conditions where we varied the length of time that subservient mice were exposed to aggr...
ORGANISM(S): Mus musculus 
2013-12-04 | E-GEOD-52866 | biostudies-arrayexpress
TranscriptomicsTime course of Streptomyces coelicolor: M145 Control vs. wblA deletion mutant
The basic experiment is a comparison of gene transcript levels of Streptomyces coelicolor M145 and its wblA deletion mutant at 6 timepoints (24, 36, 48, 60, 72 and 84 hours) encompassing vegetative growth, aerial growth, and sporulation on solid medium. The wblA mutant is morphologically defective, ...
ORGANISM(S): Streptomyces coelicolor 
2011-01-28 | E-GEOD-24396 | biostudies-arrayexpress
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