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ProteomicsThe ubiquitin ligase UBR5 suppresses proteostasis collapse in immortal pluripotent stem cells and Huntington’s disease models
Pluripotent stem cells undergo unlimited self-renewal while maintaining their potential to differentiate into post-mitotic cells with an intact proteome, a capacity that demands a highly induced proteostasis network. As such, induced pluripotent stem cells (iPSCs) suppress the aggregation of polyQ-e...
ORGANISM(S): Homo sapiens (Human) 
2018-06-14 | PXD009803 | Pride
Human cells (293) Htt 
ProteomicsComparison non-targeting hRNA hESCs versus UBE2K shRNA hESCs
Histones modulate gene expression by chromatin compaction, regulating numerous processes such as differentiation. However, the mechanisms underlying histone degradation remain elusive. When compared with their differentiated counterparts, immortal human embryonic stem cells (hESCs) have a unique chr...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD018625 | Pride
Histones Ubiquitin proteasome system Hescs 
ProteomicsIdentification of ubiquitination sites of purified histone H3
Histones modulate gene expression by chromatin compaction, regulating numerous processes such as differentiation. However, the mechanisms underlying histone degradation remain elusive. When compared with their differentiated counterparts, immortal human embryonic stem cells (hESCs) have a unique chr...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD018621 | Pride
Epigenetics Ubiquitination Histone h3 
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
UnknownStandards of NGS Data Sharing and Analysis in Ataxias: Recommendations by the NGS Working Group of the Ataxia Global Initiative.
Not available
S-EPMC10951009 | biostudies-literature
TranscriptomicsDeep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of 1-methylnicotinamide (MNA) and nicotinic acid (NA)
Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan of different species. Contrasting recent observations, we here find that overexpression of sir-2.1, the orthologue of mammalian SirT1, does extend C. elegans lifespan. Sirtuins are known to convert NAD+ i...
ORGANISM(S): Caenorhabditis elegans 
2013-08-09 | E-GEOD-49662 | biostudies-arrayexpress
ModelsThiele2013 - Human metabolism global reconstruction (Recon 2)
Thiele2013 - Human metabolism global reconstruction (Recon 2) Community-driven global reconstruction of human metabolism (version 2.02). This model is described in the article: A community-driven global reconstruction of human me...
2005-01-01 | MODEL1109130000 | BioModels
ModelsThiele2013 - Cerebellum cells in granular layer
Thiele2013 - Cerebellum cells in granular layer The model of cerebellum cells in granular layer metabolism is derived from the community-driven global reconstruction of human metabolism (version 2.02, MODEL1109130000 ). This model i...
2005-01-01 | MODEL1310110000 | BioModels
ModelsThiele2013 - Adrenal gland glandular cells
Thiele2013 - Adrenal gland glandular cells The model of adrenal gland glandular cells metabolism is derived from the community-driven global reconstruction of human metabolism (version 2.02, MODEL1109130000 ). This model is describe...
2005-01-01 | MODEL1310110001 | BioModels
ModelsThiele2013 - Spleen cells in white pulp
Thiele2013 - Spleen cells in white pulp The model of spleen cells in white pulp metabolism is derived from the community-driven global reconstruction of human metabolism (version 2.02, MODEL1109130000 ). This model is described in t...
2005-01-01 | MODEL1310110002 | BioModels
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