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TranscriptomicsIntracranial self-stimulation regulates gene expression in rat hippocampus
Transcriptional profiling of rat hippocampus 4.5h post intracranial self-stimulation (ICSS) show that this treatment, which improves learning and memory processes in a variety of paradigms of implicit and explicit memory, regulates gene expression of genes related to cAMP-mediated signaling and regu...
ORGANISM(S): Rattus norvegicus 
2013-09-03 | E-GEOD-42793 | biostudies-arrayexpress
MetabolomicsGluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei
Bloodstream form African trypanosomes are thought to rely exclusively upon glycolysis, using glucose as a substrate, for ATP production. Indeed, the pathway has long been considered a potential therapeutic target to tackle the devastating and neglected tropical diseases caused by these parasites. Ho...
2018-12-10 | MTBLS706 | MetaboLights
UnknownOverall Survival and Long-Term Safety of Nivolumab (Anti-Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer.
Not available
S-EPMC4672027 | biostudies-literature
ProteomicsPrecision-edited histone tails perturb polycistronic gene expression controls in trypanosomes
Transcription of protein coding genes in trypanosomatids is atypical and almost exclusively polycistronic. In Trypanosoma brucei, approximately 150 polycistrons, and 8000 genes, are constitutively transcribed by RNA polymerase II, while a smaller subset can be transcribed by RNA polymerase I. RNA po...
ORGANISM(S): Trypanosoma brucei 
2025-03-11 | PXD061709 | Pride
Trypanosomes h4 t. brucei polycistronic expression control 
ProteomicsOrigins and consequences of kinetoplast loss in trypanosomes
The kinetoplast is the large mitochondrial genome present in the eponymous Kinetoplastida. African trypanosomes can lose their kinetoplast DNA (kDNA), however, when the nuclear-encoded gamma subunit of the mitochondrial ATP-synthase (g-ATPase) is mutated. These mutations are also associated with mul...
ORGANISM(S): Trypanosoma brucei 
2025-12-13 | PXD071938 | Pride
Trypanosoma brucei Mutagenesis Editing Genome Drug resistance Kinetoplastid 
ProteomicsControl of variant surface glycoprotein expression by CFB2 in African trypanosomes and quantitative proteomic connections to translation and cytokinesis initiation
Variant Surface Glycoproteins (VSG) coat parasitic African trypanosomes and underpin antigenic variation and immune evasion. This VSG is a super-abundant virulence factor that is subject to post-transcriptional gene expression controls mediated via the VSG 3’-untranslated region (3’-UTR). To identif...
ORGANISM(S): Trypanosoma brucei 
2022-02-01 | PXD031351 | Pride
Mrna-binding  pbp1 Trypanosoma brucei  mkt1 Proteomics  rnai. 
ProteomicsA non-coding role for trypanosome VSG transcripts in allelic exclusion
Bloodstream-form African trypanosomes display mono-telomeric expression of a Variant Surface Glycoprotein (VSG) gene in an inter-chromosomally bridged transcription and splicing compartment, such that the dominant gene produces 10,000 times more transcript than excluded VSG genes. Antigenic variatio...
ORGANISM(S): Trypanosoma brucei 
2025-03-11 | PXD060524 | Pride
Antigenic variation Trypanosoma brucei. Cncrna Monoallelic 
TranscriptomicsAnalysis of the Cerebral Cortex and Hippocampus Transcriptome Reveals Unique Molecular Changes in the Ts1Cje Mouse Model of Down Syndrome
Down syndrome is characterized by a complex phenotype that includes developmental disabilities and congenital anomalies. The molecular origin of these abnormalities is poorly understood. The objective of this study is to analyze whole transcriptome changes in the cortex and hippocampus of the Ts1Cje...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-49635 | biostudies-arrayexpress
ProteomicsVEX1-GFP Pull-downs - Affinity-purified VEX1GFP-associated proteins using cryomilling and high-affinity nanobodies
We affinity-purified VEX1GFP-associated proteins using cryomilling and high-affinity nanobodies. The procedure was carried out initially in insect-stage T. brucei, for which protocols were established, and then in bloodstream-form T. brucei. Quantitative proteomic analysis revealed tag-dependent enr...
ORGANISM(S): Trypanosoma brucei 
2019-05-31 | PXD013304 | Pride
Vex1  vsg  allelic exclusion  trypanosoma brucei 
ProteomicsA post-transcriptional respiratome regulon in trypanosomes
Post-transcriptional regulons coordinate the expression of groups of genes in eukaryotic cells, yet relatively few have been characterised. Parasitic trypanosomatids are particularly good models for studies on such mechanisms because they exhibit almost exclusive polycistronic, and unregulated, tran...
ORGANISM(S): Trypanosoma brucei 
2019-11-13 | PXD012450 | Pride
Silac Zc3h39/40 Trypanosoma brucei 
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