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ProteomicsAmyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity
Here, we combine cryo-electron tomography, proteomics and cell biology studies to investigate the effects of protein aggregates in primary neurons. We use artificial amyloid-like β-sheet proteins (β proteins) to focus on the gain-of-function aspect of aggregation. These proteins form fibrillar aggre...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-20 | PXD029689 | Pride
Neurons Toxic proteins Protein aggregates Neurodegeneration 
OtherDeep proteomic evaluation of primary and cell line motoneuron disease models delineates major differences in neuronal characteristics
Data from ProteomeXchange, PXD ID: PXD000666. File: 20120710_EXQ4_DaHo_SA_labelfree_7D_MN1_3_12_2.mzml. Published as part of Mol Cell Proteomics. 2014 Sep 5 . From the Abstract: {{i}} The fatal neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are the ...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320003403 | GPMDB
Resource Reanalysis 
ProteomicsEnhanced competition at the nano-bio interface enables comprehensive characterization of protein corona dynamics and deep coverage of proteomes
We demonstrate the importance of the protein to NP-surface ratio (P/NP) and model protein corona formation dynamics, which determine the competition between proteins for binding.
ORGANISM(S): Homo sapiens (Human) 
2022-09-02 | PXD030327 | Pride
Nano-bio interactions Proteomics Mass spectrometry Nanoparticles Protein corona Machine learning Vroman effect 
ProteomicsThe Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High Performance Quadrupole and an Ultra-High Field Orbitrap Analyzer
The quadrupole Orbitrap mass spectrometer (Q Exactive) has made a powerful proteomics instrument available in a benchtop format. It significantly boosted analyzable proteins per hour and has now evolved into a proteomics analysis workhorse for many laboratories. Here we describe the Q Exactive Plus ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080865 | MassIVE
MetabolomicsLongitudinal Deep Multi-Omics Profiling in aCLN3Δex7/8Minipig Model Reveals Novel Biomarker Signatures for Batten Disease
Development of therapies for CLN3 Batten disease, a rare pediatric lysosomal storage disorder, has been hindered by the lack of etiological insights and translatable biomarkers to clinics. Here, we used a deep multi-omics approach to discover new biomarkers using longitudinal serum samples from a po...
2025-08-13 | MTBLS1107 | MetaboLights
ProteomicsSocial Network Architecture of Human Immune Cells Unveiled by Quantitative Proteomics
The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not been established. Here, we applied high-resolution mass spectrometry-based proteomics to generate a publicly accessible pro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-05-16 | MSV000081089 | MassIVE
ProteomicsSocial Network Architecture of Human Immune Cells Unveiled by Quantitative Proteomics
The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not been established. Here, we applied high-resolution mass spectrometry-based proteomics to generate a publicly accessible pro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-03 | MSV000096281 | MassIVE
ProteomicsDeep proteomic evaluation of primary and cell line motoneuron disease models delineates major differences in neuronal characteristics
The fatal neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are the most common motoneuron disease and genetic cause of infant death, respectively. Various in vitro model systems have been established to investigate motoneuron disease mechanisms - in p...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-08 | MSV000084939 | MassIVE
ProteomicsH.sapiens - Cell line, SC (Scheltemaetal,molcellproteomics,2014)
abundance based on Spectral counting, Interaction consistency score: 19.1, Coverage: 27
ORGANISM(S): 9606 
2014-00-00 | 4132152676 | PAXDB
ProteomicsThe impact II, a very high resolution quadrupole time-of-flight instrument for deep shotgun proteomics
Hybrid quadrupole time-of-flight (QTOF) is one of the two major mass spectrometric technologies used in proteomics. Although based on simple fundamental principles, it has over the last decades greatly evolved in terms of achievable resolution, mass accuracy and dynamic range. The Bruker impact plat...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Saccharomyces Cerevisiae (ncbitaxon:4932) Mus Musculus (ncbitaxon:10090) 
2016-07-19 | MSV000079935 | MassIVE
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