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ProteomicsProteomic identification of monoclonal antibodies from rabbit serum and analysis of FDR using differential cysteine labeling
Proteomic analysis of serum antibodies is challenging due to the non-germline origin of immunoglobulin (Ig) sequences and the complexity of Ig primary structure, with regions of hypervariable sequence interspersed within highly conserved framework sections resulting in an unusually high frequency of...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2014-04-24 | PXD000916 | Pride
Lc-msms Orbitrap velos Rabbit Antibody Igg 
ProteomicsProteomic identification of anti-tetanus toxoid antibodies from human serum (HD1)
Proteomic identification and characterization of antibodies comprising the serological response to antigen can provide unique insight into the functional dynamics of adaptive immunity. We have developed a novel method to overcome the technical challenges which previously limited the direct analysis...
ORGANISM(S): Homo sapiens (Human) 
2014-04-24 | PXD000917 | Pride
Lc-msms Orbitrap velos Human Igg Antibody proteomics 
ProteomicsLongitudinal proteomic analysis of influenza HA-reactive IgG antibody repertoire over multiple years and repeated vaccinations
Longitudinal proteomic analysis of H1N1 A/California/7/2009 (CA09) hemagglutinin (HA)-reactive serum IgG antibody repertoire over 5 years and multiple (yearly) vaccinations (both pre- and post-vaccination samples) in a donor. Dataset consists of steady-state (pre-vaccination at day 0) and peak-respo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-11-08 | MSV000083120 | MassIVE
ProteomicsIdentification of SARS-COV-2 specific antibodies from patient serum during the First Wave of the COVID-19 pandemic
Proteomic Ig-SEQ identification of SARS-COV-2 specific antibodies from serum of two convalescent patients during the first wave of the COVID-19 pandemic. Total IgG was isolated from serum, digested with IdeS protease to generate F(ab)2 fragments, and subjected to antigen affinity chromatography usin...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046829 | Pride
Igg Human Ig-seq Serum antibody profiling Sars-cov-2 Orbitrap fusion lumos Lc-msms 
ProteomicsMitochondrial Protein Hyperacetylation in the Failing Heart
Mitochondrial proteomics was used to identify energy metabolic derangements that occur during the early stages of heart failure in well-defined mouse models. Levels of β-hydroxybutyrate dehydrogenase 1 (BDH1), a key enzyme in ketone oxidation, was upregulated. 13C-substrate flux studies and metabol...
ORGANISM(S): Mus musculus (Mouse) 
2016-02-26 | PXD001652 | Pride
Heart failure Acetylation Mitochondria 
UnknownTwo Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.
Not available
S-EPMC10794000 | biostudies-literature
UnknownTherapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
Not available
S-EPMC8362594 | biostudies-literature
UnknownProtecting stable biological nomenclatural systems enables universal communication: A collective international appeal.
Not available
S-EPMC11328142 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
UnknownAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC7884931 | biostudies-literature
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