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TranscriptomicsDEPTOR cell-autonomously promotes adipogenesis and associates with obesity
An understanding of the mechanisms regulating white adipose tissue (WAT) formation is key for developing of new tools to treat obesity and its related diseases. Here, we identify DEPTOR as a positive regulator of adipogenesis whose expression is associated with obesity. In a polygenic mouse model of...
ORGANISM(S): Mus musculus 
2012-08-14 | E-GEOD-38321 | biostudies-arrayexpress
TranscriptomicsLiver transcriptome comparison of divergently selected Lean and Fat mouse lines in cholesterol homeostasis, bile acids, glucose and lipoprotein metabolism
This study aimed to identify molecular basis of obesity-resistant mechanisms in the Lean line with the emphasis on lipid homeostasis. Expression profiling using custom Steroltalk v2 microarray demonstrated that Lean mice exhibit a higher hepatic expression of cholesterol synthesis genes compared to ...
ORGANISM(S): Mus musculus 
2011-10-16 | E-GEOD-24967 | biostudies-arrayexpress
TranscriptomicsFob3b vs F-line
Liver and BAT expression differences between the fat F-line, and congenic Fob3b-line. Normalised data appended as follows: TABLE 1: LIVER - 1st set (7.5K) of the 2 slide NIA NIH 15K set -source1 = F-line liver male - 2 pools each made from 5 different individuals -source2 = Fob3b-line (aka Fchr15D-...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-1558 | biostudies-arrayexpress
UnknownExamining genotype-phenotype associations of GRAM domain proteins using GWAS, PheWAS and literature review in cattle, human, pig, mouse and chicken.
Not available
S-EPMC11582632 | biostudies-literature
UnknownWhole genome sequencing of mouse lines divergently selected for fatness (FLI) and leanness (FHI) revealed several genetic variants as candidates for novel obesity genes.
Not available
S-EPMC11024027 | biostudies-literature
UnknownGenome-wide screening for genetic variants in polyadenylation signal (PAS) sites in mouse selection lines for fatness and leanness.
Not available
S-EPMC9684942 | biostudies-literature
UnknownIntracranial and Cerebral Perfusion Pressure Thresholds Associated With Inhospital Mortality Across Pediatric Neurocritical Care.
Not available
S-EPMC7855782 | biostudies-literature
ProteomicsSuper-paramagnetic iron oxide nanoparticles reprogram the tumor microenvironment and reduce lung cancer growth
Tumor associated macrophages (TAMs) are known to play a role in a multitude of processes that facilitate lung cancer growth, including the suppression of tumoricidal immune activation and the absorption of chemotherapeutics. Therefore, deciphering new therapies to reprogram TAMs towards an anti-tumo...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-18 | PXD040145 | Pride
Macrophages Immunotherapy Spion Iron Lung cancer 
UnknownNeuroticism personality traits are linked to adverse cardiovascular phenotypes in the UK Biobank.
Not available
S-EPMC10610755 | biostudies-literature
UnknownHeritability of Coronary Artery Disease: Insights From a Classical Twin Study.
Not available
S-EPMC8925867 | biostudies-literature
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