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UnknownPredicted leukocyte telomere length and risk of myeloid neoplasms.
Maintenance of telomere length has long been established to play a role in the biology of cancer and several studies suggest that it may be especially important in myeloid malignancies. To overcome potential bias in confounding and reverse causation of observational studies, we use both a polygenic ...
S-EPMC10549790 | biostudies-literature
UnknownGenome-Wide DNA Methylation Profiles in Whole-Blood and Buccal Samples-Cross-Sectional, Longitudinal, and across Platforms.
The field of DNA methylation research is rapidly evolving, focusing on disease and phenotype changes over time using methylation measurements from diverse tissue sources and multiple array platforms. Consequently, identifying the extent of longitudinal, inter-tissue, and inter-platform variation in ...
S-EPMC10572275 | biostudies-literature
UnknownBlood-Based EWAS of Asthma Polygenic Burden in The Netherlands Twin Register.
Asthma, a chronic respiratory condition characterized by airway inflammation, affects millions of individuals worldwide. Challenges remain in asthma prediction and diagnosis from its complex etiology involving genetic and environmental factors. Here, we investigated the relationship between genome-w...
S-EPMC11852504 | biostudies-literature
UnknownPredicting Complex Traits and Exposures From Polygenic Scores and Blood and Buccal DNA Methylation Profiles.
We examined the performance of methylation scores (MS) and polygenic scores (PGS) for birth weight, BMI, prenatal maternal smoking exposure, and smoking status to assess the extent to which MS could predict these traits and exposures over and above the PGS in a multi-omics prediction model. MS may b...
S-EPMC8357987 | biostudies-literature
UnknownPolygenic scores for dizygotic twinning: insights into the genetic architecture of female fertility.

Purpose

Natural dizygotic twinning (DZT) results from hyper-ovulation and is an indicator of female fertility. However, some traits linked to DZ twinning are also associated with infertility. We examined the relationship between DZT and female (in)fertility using recent GWAS findings.

Met...

S-EPMC12356781 | biostudies-literature
UnknownPolygenic Scores for Dizygotic Twinning: Insights into the Genetic Architecture of Female Fertility.
Natural dizygotic twinning (DZT) results from hyper-ovulation and is considered an indicator of female fertility. DZT has low polygenicity, with only 0.20% of SNPs estimated to have a nonzero effect. A polygenic score (PGS) for DZT explains 1.6% of variance in DZT liability and we observe an odds ra...
S-EPMC11908296 | biostudies-literature
UnknownEpigenetic signatures of asthma: a comprehensive study of DNA methylation and clinical markers.

Background

Asthma, a complex respiratory disease, presents with inflammatory symptoms in the lungs, blood, and other tissues. We investigated the relationship between DNA methylation and 35 clinical markers of asthma.

Methods

The Illumina Infinium EPIC v1 methylation array was used to...
S-EPMC11531182 | biostudies-literature
UnknownGenome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs.

Background

DNA methylation arrays are widely used in epigenome-wide association studies and methylation quantitative trait locus (mQTL) studies. Here, we performed the first genome-wide analysis of monozygotic (MZ) twin correlations and mQTLs on data obtained with the Illumina MethylationEPI...
S-EPMC6156977 | biostudies-literature
UnknownIdentical twins carry a persistent epigenetic signature of early genome programming.
Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-implantation stages of development. The mechanisms underpinning this event have remained a mystery. Because MZ twinning rarely runs in families, the leading hypothesis is that it occurs at random. Here, we show t...
S-EPMC8479069 | biostudies-literature
UnknownUnidirectional and bidirectional causation between smoking and blood DNA methylation: evidence from twin-based Mendelian randomisation.
Cigarette smoking is associated with numerous differentially-methylated genomic loci in multiple human tissues. These associations are often assumed to reflect the causal effects of smoking on DNA methylation (DNAm), which may underpin some of the adverse health sequelae of smoking. However, prior c...
S-EPMC11799127 | biostudies-literature
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