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While cell models are routinely used to study cardiac molecular biology, in vitro systems fall far short of mimicking the metabolic and sarcomere structural maturity of intact cardiac tissue. Achieving a mature cardiomyocyte (CM) phenotype is essential for creating a physiologically relevant environ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD074288 | Pride
Introduction: Adipose tissue is a complex endocrine organ and active participant in the initiation and progression of metabolic disorders such as obesity and diabetes. While often overlooked, calcium uptake and cycling in the endoplasmic reticulum (ER) are known to play key roles in glucose homeosta...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-16 | PXD059431 | Pride
Organelles like lysosomes and synaptic vesicles are acidified by V-ATPases, which consist of a cytosolically-oriented V1 complex that hydrolyzes ATP and a membrane-embedded VO complex that pumps protons. In yeast, V1-VO association is facilitated by the RAVE complex, but how higher eukaryotes assemb...
ORGANISM(S): Homo sapiens (Human) 
2025-05-20 | PXD064067 | Pride
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