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ProteomicsPhosphorylation activates the yeast small heat shock protein Hsp26 by weakening domain contacts in the oligomer ensemble
Hsp26 is a small heat shock protein (sHsp) from S. cerevisiae. It is known to be activated by dissociation of the oligomer at heat shock temperatures. We wondered whether phosphorylation regulates its activity at physiological temperatures. In Hsp26, 9 phosphorylation sites which are located in diff...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-12-17 | PXD025314 | Pride
Hsp26 Phosphorylation Shsp 
ProteomicsStructural probing of Hsp26 activation and client binding by quantitative cross-linking mass spectrometry
Small heat-shock proteins (sHSP) are important members of the cellular stress response in all species. Their best described function is the binding of early unfolding states and the resulting prevention of protein aggregation. All sHSPs exist as oligomers but vary in size and subunit organization. S...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-13 | PXD026244 | Pride
Chaperones Hsp26 Shsps Ssa1 Qxl-ms Xl-ms Refolding complex Ydj1 
ProteomicsProteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in lifespan extension C4PR_LIV
Dietary restriction (DR) has been shown to increase lifespan in organisms ranging from yeast to mammals. This suggests that the underlying mechanisms may be evolutionarily conserved. Indeed, upstream signalling pathways, such as TOR, are strongly linked to DR-induced longevity in various organisms. ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-17 | PXD025004 | Pride
Mitochondria Chaperone Calorie restriction Saccharomyces cerevisiae Aging 
UnknownPhosphorylation activates the yeast small heat shock protein Hsp26 by weakening domain contacts in the oligomer ensemble.
Not available
S-EPMC8602628 | biostudies-literature
UnknownA chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104.
Not available
S-EPMC1391974 | biostudies-literature
UnknownPop2 phosphorylation at S39 contributes to the glucose repression of stress response genes, HSP12 and HSP26.
Not available
S-EPMC6459547 | biostudies-literature
UnknownProteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension.
Not available
S-EPMC8786290 | biostudies-literature
UnknownThe molecular characterization and expression of heat shock protein 90 (Hsp90) and 26 (Hsp26) cDNAs in sea cucumber (Apostichopus japonicus).
Not available
S-EPMC3156262 | biostudies-literature
TranscriptomicsCold hardening gene expression
Cold hardening treatment, a brief exposure to low temperatures (e.g. 0°C for 2 h), can protect certain insects against subsequent exposure to temperatures sufficiently low to cause damage or lethality. Microarray analysis to examine the changes in transcript abundance associated with cold hardening ...
ORGANISM(S): Drosophila melanogaster 
2005-11-30 | E-GEOD-2989 | biostudies-arrayexpress
UnknownAn ABF5b-HsfA2h/HsfC2a-NCED2b/POD4/HSP26 module integrates multiple signaling pathway to modulate heat stress tolerance in wheat.
Not available
S-EPMC12576446 | biostudies-literature
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