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ProteomicsToxoplasma gondii Tgj1 Hsp40 protein interaction LC-MS/MS
We identified an Hsp40 Ydj1 / Hdj2 ortholog in T. gondii, which is involved in various biological roles in T. gondii as deduced from its interactome and analysis of the ΔCXXX mutant. Among these roles are differentiation and DNA damage, as well as metabolic pathways such as translation and energy ge...
ORGANISM(S): Toxoplasma gondii 
2023-05-10 | PXD024656 | Pride
Toxoplasma Gondii hsp40 Interaction 
GenomicsMechanisms of assembly and function of the Hsp70-Hsp40 chaperone machinery
Mechanisms of assembly and function of the Hsp70-Hsp40 chaperone machinery
PRJNA1306495 | ENA
OtherMechanisms of assembly and function of the Hsp70-Hsp40 chaperone machinery
Hsp70 and Hsp40 molecular chaperones form a central machinery that remodels client proteins involved in numerous biological processes. Here, we integrated cryo-electron microscopy and nuclear magnetic resonance spectroscopy to determine the architecture of the full-length Hsp70-Hsp40 machinery. The ...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2025-10-15 | GSE305556 | GEO
ProteomicsAcetylation of the yeast Hsp40 chaperone protein Ydj1 regulates proteostasis and translational fidelity
In this study, we set out to clarify the role of lysine acetylation on the major yeast Hsp40, Ydj1. We mutated a series of acetylation sites on Ydj1s J domain to either arginine to block acetylation or glutamine to mimic constitutive acetylation.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2024-04-14 | MSV000094536 | MassIVE
TranscriptomicsThermoprotection in the Drosophila hsf4 mutant
In Drosophila larvae, acquired synaptic thermotolerance following heat shock has previously been shown to correlate with the induction of heat shock proteins (Hsps) including HSP70. We tested the hypothesis that synaptic thermotolerance would be significantly diminished in a temperature-sensitive st...
ORGANISM(S): Drosophila melanogaster 
2005-11-30 | E-GEOD-2998 | biostudies-arrayexpress
ProteomicsThe HSP40 chaperone Ydj1/DnaJA1 drives amyloid beta toxicity
Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD); however, the etiology of Abeta42 toxicity remains elusive. In a proteomic approach using a yeast model for intracellular Abeta42 toxicity, we here identify the HSP40 family member Ydj1, the yeast...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-04-27 | PXD012612 | Pride
Lc-ms/ms Alzheimer’s disease Yeast Saccharomyces cerevisiae Silac 
UnknownThe roles of a flagellar HSP40 ensuring rhythmic beating.
Not available
S-EPMC6589562 | biostudies-literature
UnknownStructural basis for client recognition and activity of Hsp40 chaperones.
Not available
S-EPMC7023980 | biostudies-literature
UnknownInfluenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
Not available
S-EPMC3115951 | biostudies-literature
UnknownDnaJ/Hsp40 Family and Parkinson's Disease.
Not available
S-EPMC5767785 | biostudies-literature
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