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ProteomicsA Chemoproteomic Atlas of the Human Purine Interactome for Regioselective Ligand Discovery
Purines are essential bioactive molecules that interact with a large fraction of the human proteome. Despite their importance, the scope of actionable purine-binding pockets for ligand discovery remains limited. Here, we developed a quantitative chemoproteomics platform using sulfonyl-purine (SuPUR)...
ORGANISM(S): Homo sapiens (Human) 
2026-03-29 | PXD075707 | Pride
ProteomicsA Chemoproteomic Atlas of the Human Purine Interactome for Regioselective Ligand Discovery
Purines are essential bioactive molecules that interact with a large fraction of the human proteome. Despite their importance, the scope of actionable purine-binding pockets for ligand discovery remains limited. Here, we developed a quantitative chemoproteomics platform using sulfonyl-purine (SuPUR)...
ORGANISM(S): Homo sapiens (Human) 
2026-03-29 | PXD071955 | Pride
ProteomicsA Covalent PFKL Activator Suppresses Tumor Growth
Glycolysis fuels vital cellular functions and its dysregulation is implicated in cancer, neurodegeneration, antibiotic resistance and diabetes. The glycolytic dependency of cancer, known as the Warburg effect, presents a key vulnerability for developing targeted anticancer agents but remains challen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-18 | PXD078921 | Pride
Pfkl Edc Covalent activator Tumor supression Glycolysis 
ProteomicsSulfonyl-Imidazopyridines Decouple Reactivity from Stability for Ligandability Mapping and Covalent Inhibitor Discovery
Covalent probes and therapeutics require a balance between sufficient reactivity toward protein sites and stability for function in biological systems, yet enhancing stability often attenuates electrophilicity, constraining ligand discovery. Here, we show that single-atom N-to-C substitutions of sul...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-21 | PXD079357 | Pride
Chemoproteomics 
TranscriptomicsProstate Cancer Gene Expression Changes after Treatment with Neoadjuvant Dutasteride
To identify molecular changes underlying the chemopreventive or tumor promoting effects of SRD5A inhibition, we profiled gene expression changes in benign prostate epithelium from patients with PCa treated with dutasteride, a dual SRD5A inhibitor. Subjects were aged 45-80 years with clinically local...
ORGANISM(S): Homo sapiens 
2008-12-01 | E-GEOD-9972 | biostudies-arrayexpress
UnknownDiscovery and Optimization of a Covalent AKR1C3 Inhibitor.
Not available
S-EPMC12710241 | biostudies-literature
UnknownA Glutathione S-Transferase Pi Molecular Glue Tethers Splicing Factors and Remodels Cell Metabolism.
Not available
S-EPMC12753042 | biostudies-literature
ProteomicsChemoproteomic capture of RNA binding activity in living cells
Proteomic methods for RNA interactome capture (RIC) rely principally on crosslinking native or labeled cellular RNA to enrich and investigate RNA-binding protein (RBP) composition and function in cells. The ability to measure RBP activity at individual binding sites by RIC, however, has been more ch...
ORGANISM(S): Homo sapiens (Human) 
2023-10-10 | PXD044625 | Pride
Lc-msms Chemoproteomics Human Chemical biology Rna-binding protein Rna interactome 
UnknownHuman PTGR2 Inactivation Alters Eicosanoid Metabolism and Cytokine Response of Inflammatory Macrophages.
Not available
S-EPMC12710877 | biostudies-literature
UnknownA simple strategy for the creation of a recombinant lectin microarray.
Not available
S-EPMC8375558 | biostudies-literature
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