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TranscriptomicsWhole genome gene expression profiling in CD4+ T-cells, FACS-sorted based on CADM1/CD7 expression levels, in Adult T-cell Leukemia-lymphoma (ATL) patients, HTLV-1 carriers, and in healthy volunteers.
CADM1 overexpresion and stepwise downregulation of CD7 in CD4+T-cells from ATL patients and HTLV-1 carriers accurately reflect the process of disease, i.e., oligoclonally and clonally exanding cells are accumulated in D (CADM1posCD7dim) and N (CADM1posCD7neg) populations, respectively. Moreover, gen...
ORGANISM(S): Homo sapiens 
2014-06-02 | E-GEOD-55851 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiles of cloned CD4+ and CD8+ T cells infected or not by HTLV-1 in vivo
To address whether changes in miRNA expression accompany cell-associated replication of HTLV-1 in vivo, we carried out the miRNA expression profiling of CD4+ and CD8+ T-cells derived from naturally HTLV-1 infected individuals with no clinical sign of malignancy. T-cell clones were obtained by limiti...
ORGANISM(S): Homo sapiens 
2014-12-03 | E-GEOD-46345 | biostudies-arrayexpress
TranscriptomicsTranscriptional and post-transcriptional analysis of CD4+ T cell clones deriving from HTLV-1 infected individuals
T-cell clones were obtained by limiting dilution culture of PBMC of HTLV-1 carriers. Exon expression profiling was performed using Affymetrix exon array (Affymetrix Human Exon 1.0 ST Array) according to the manufacturer's instructions. The main objectives were to assess whether transcriptional and p...
ORGANISM(S): Homo sapiens 
2014-12-03 | E-GEOD-46518 | biostudies-arrayexpress
TranscriptomicsRoles for microRNAs, miR-93 and miR-130b, and TP53INP1 tumor suppressor in cell growth dysregulation by HTLV-1
This is to study the role of miRNAs in human T-cell leukemia virus-1, HTLV-1. In this study, we profiled the miRNA expression in virus transformed human cell lines and primary peripheral blood mononuclear cells (PBMCs) from Adult-T cell leukemia (ATL) patients using the RNA-primed, array-based Kleno...
ORGANISM(S): Homo sapiens 
2008-06-06 | E-GEOD-11577 | biostudies-arrayexpress
ProteomicsKDR-dependent tyrosine phosphorylation in HTLV-1 transformed cells
Human T-cell leukemia virus type 1 (HTLV-1) is linked to the development of adult T-cell leukemia (ATL) and the neuroinflammatory disease, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 Tax oncoprotein regulates viral gene expression and the NF-kB pathway to promote ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-14 | PXD051981 | Pride
Tax Kdr Vegfr2 Htlv-1 
ProteomicsHTLV-1 Rex hijacks UPF1 in a CRM1 dependent manner, leading to NMD inhibition and revealing proviral roles of UPF1.
The hijacking of CRM1 export is an important step of the retroviral replication cycle. Here, we investigated the consequences of this hijacking for the host. During HTLV-1 infection, we identified the formation of a complex composed of REX, CRM1 and the RNA helicase UPF1, leading to the nuclear rete...
ORGANISM(S): HTLV-1 subtype A 
2025-05-14 | PXD043988 | Pride
Mass spectrometry Htlv-1 Upf1 
Transcriptomicsgene expression profiling in CD69 positive blood cells selected from Healthy blood Donors and HTLV-1-infected patients
The goal of the study was to identify difference in gene expression between activated /CD69+ blood cells selected from HTLV-1-infected patient displaying HAM-TSP disease (HTLV-1-associated myelopathy/tropical spastic paraparesis), compared to healthy blood donor /HD (biological sample providers: Dr....
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-33859 | biostudies-arrayexpress
TranscriptomicsMouse Dendritic and Antigen Presenting Cell RTM-BM-2 Profiler PCR
Infection of mouse bone marrow Flts3L-derived dendritic cells (FL-DCs) with chimeric human T cell leukemia virus type 1 (HTLV-1) results in the upregulation as well as selective downregulation of various DC-specific genes. Mouse bone marrow Flt3L-derived dendritic cells were infected with chimeric H...
ORGANISM(S): Mus musculus 
2010-10-28 | E-GEOD-24959 | biostudies-arrayexpress
TranscriptomicsMouse Interferon M-NM-1, M-NM-2 RTM-BM-2 Profiler PCR
Infection of mouse bone marrow Flts3L-derived dendritic cells (FL-DCs) with chimeric human T cell leukemia virus type 1 (HTLV-1) results in the upregulation as well as selective downregulation of various interferon-stimulated genes. Mouse bone marrow Flt3L-derived dendritic cells were infected with ...
ORGANISM(S): Mus musculus 
2010-10-28 | E-GEOD-24957 | biostudies-arrayexpress
TranscriptomicsTranscription factor profiling of T cells containing stably integrated or transiently transfected HTLV-1 LTR.
Transcription factor profiling of T cells containing stably integrated or transiently transfected HTLV-1 LTR. Nuclear extract from one million stably or transiently transfected Jurkat (CD4 T cell) cell line was extracted and labeled with TransSignal Probe mix (Panomics) and then hybridized to the ar...
ORGANISM(S): Homo sapiens 
2011-11-12 | E-GEOD-33628 | biostudies-arrayexpress
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