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TranscriptomicsExpression data from Bovine leukemia virus (BLV) Tax-transfected HeLa cells
Bovine leukemia virus (BLV) Tax is a transcriptional activator of viral replication and a key contributor to oncogenic potential. We previously identified interesting mutant forms of Tax with elevated (TaxD247G) or reduced (TaxS240P) transactivation effects on BLV replication and propagation. In th...
ORGANISM(S): Homo sapiens 
2013-01-03 | E-GEOD-35823 | biostudies-arrayexpress
TranscriptomicsProfile of gene expression in Tax positive (TaxP) cells compared with Tax negative (TaxN) cells.
Investigating the effect of Tax protein on the expression of genes in Jurkat cells. Current study will help us to elucidate the differential gene expression profiles of Tax positive Jurkat cells. The Tax-positive (TaxP) and Tax negative (TaxN) subline of Jurkat were established. mRNA isolated from ...
ORGANISM(S): Homo sapiens 
2012-07-26 | E-GEOD-39601 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of Jurkat with stably integrated HTLV1-LTR in the presence of HTLV-1 Tax
RNA interference (RNAi) is a natural cellular mechanism to silence gene expression and is predominantly mediated by microRNAs (miRNAs) that target messenger RNA. Viruses can manipulate the cellular processes necessary for their replication by targeting the host RNAi machinery. This study explores th...
ORGANISM(S): Homo sapiens 
2012-08-08 | E-GEOD-39986 | biostudies-arrayexpress
TranscriptomicsRNA Expression Data from IL-15-/- and IL-15+/+ TAX-LUC Mouse Tumors
IL-15 is recognized as a promising candidate for tumor immunotherapy and has been described as both a promoter of cancer and a promoter of anti-cancer immunity. IL-15 was discovered in cells transformed by HTLV-1, the etiologic agent of adult T cell leukemia / lymphoma (ATL) and the human retrovirus...
ORGANISM(S): Mus musculus 
2013-06-11 | E-GEOD-46072 | biostudies-arrayexpress
TranscriptomicsExpression data from Human Tax transfected HeLa cell
Human T cell leukemia virus type 1 (HTLV-1) Tax is potent activator of viral and cellular gene expression that interacts with a number of cellular proteins. In this study, a large-scale host cell signaling events related to cellular proliferation were used to identify genes involved in Tax-mediated ...
ORGANISM(S): Homo sapiens 
2013-03-21 | E-GEOD-34750 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4+ T-cell line Tesi in presence and absence of Tax
The Tesi system allows analysis of HTLV-1 Tax's impact on the transcriptome of a human CD4+ T-cell which is not derived from leukemia but directly from normal human lymphocytes. By comparing cells with and without Tax, one can specifically filter for celluar genes that are either activated or repres...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-10508 | biostudies-arrayexpress
ProteomicsProximity Labeling-Based Proteome Analysis of Tax Protein and HBZ RNA using DIA-LC/MS
HTLV-1 is an oncovirus that encodes a transactivator Tax and a latent oncogene HBZ. HTLV-1 early or infectious replication depends on Tax; during HTLV-1 late infection, HBZ plays a crucial role in driving the proliferation of infected cells and maintaining viral persistence. The biphasic replication...
ORGANISM(S): Homo Sapiens 
2025-06-19 | PXD065208 |
GenomicsRNA sequencing for transcriptome comparison between HTLV-1 Tax(-) and Tax(+) cells in Adult T-cell leukemia cell lines (MT-1 and KK-1)
RNA sequencing for transcriptome comparison between HTLV-1 Tax(-) and Tax(+) cells in Adult T-cell leukemia cell lines (MT-1 and KK-1)
PRJNA427802 | ENA
GenomicsAspergillus aculeatus strain:Tax-6
Aspergillus aculeatus strain:Tax-6 Transcriptome or Gene expression
PRJNA385383 | ENA
ProteomicsKDR-dependent tyrosine phosphorylation in HTLV-1 transformed cells
Human T-cell leukemia virus type 1 (HTLV-1) is linked to the development of adult T-cell leukemia (ATL) and the neuroinflammatory disease, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 Tax oncoprotein regulates viral gene expression and the NF-kB pathway to promote ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-14 | PXD051981 | Pride
Tax Kdr Vegfr2 Htlv-1 
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