Sort   by:  
 Page size 
ProteomicsNeddylation modification on cGAS of human and mouse
The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) has emerged as a fundamental component fueling the anti-pathogen immunity. Because of its pivotal role in initiating innate immune response, the activity of cGAS must be tightly fine-tuned to maintain immune homeostasis in antiviral r...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-02-22 | PXD024088 | Pride
Human Cgas Neddylation Mouse 
TranscriptomicsEvolution of human-specific microRNA miR-941 [Ago2_IP]
miRNA-mediated gene expression silencing has previously been shown to be important for a variety of physiological and pathological processes. Here, we have explored the role of one bona fide human-specific miRNA (miR-941) in evolution of the human-specific expression and function. Using combination ...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-39227 | biostudies-arrayexpress
TranscriptomicsWidespread Expression of piRNA-like Molecules in Somatic Tissues
Piwi-interacting RNA (piRNA) are small RNA abundant in the germline across animal species. In fruit flies and mice, piRNA were implicated in maintenance of genomic integrity by transposable elements silencing. Outside of the germline, piRNA have only been found in Drosophila ovarian follicle cells. ...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-27369 | biostudies-arrayexpress
TranscriptomicsEvolution of human-specific microRNA miR-941
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Macaca mulatta 
2012-12-20 | E-GEOD-35621 | biostudies-arrayexpress
TranscriptomicsEvolution of human-specific microRNA miR-941 [cerebellum gene expression]
miRNA-mediated gene expression silencing has previously been shown to be important for a variety of physiological and pathological processes. Here, we have explored the role of one bona fide human-specific miRNA (miR-941) in evolution of the human-specific expression and function. Using combination ...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-35619 | biostudies-arrayexpress
TranscriptomicsEvolution of human-specific microRNA miR-941 [miRNA transfection]
miRNA-mediated gene expression silencing has previously been shown to be important for a variety of physiological and pathological processes. Here, we have explored the role of one bona fide human-specific miRNA (miR-941) in evolution of the human-specific expression and function. Using combination ...
ORGANISM(S): Macaca mulatta 
2012-12-20 | E-GEOD-35620 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression and regulation in human, chimpanzee, and macaque brain
Among other factors, changes in gene expression on the human evolutionary lineage have been suggested to play an important role in the establishment of human-specific phenotypes. However, the molecular mechanisms underlying these expression changes are largely unknown. Here, we have explored the rol...
ORGANISM(S): Homo sapiens 
2011-10-17 | E-GEOD-26545 | biostudies-arrayexpress
UnknownMetabolomics and biochemical assays reveal the metabolic responses to hypo-salinity stress and osmoregulatory role of cAMP-PKA pathway in Mercenaria mercenaria.
Not available
S-EPMC9385449 | biostudies-literature
TranscriptomicsEvolution of mammalian miRNA genes
MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression, yet their origins and functional evolution in mammals remain little understood due to the lack of appropriate comparative data. Using RNA sequencing, we have generated extensive and comparable miRNA data for five organs...
ORGANISM(S): Macaca mulatta 
2012-10-01 | E-GEOD-40499 | biostudies-arrayexpress
TranscriptomicsAb initio identification of transcription start sites (TSSs) in the Rhesus macaque genome by histone modification and RNA-Seq
We addressed the lack of experimentally supported transcript annotations in the Rhesus macaque genome by ab initio identification of the transcription start sites (TSSs). We took advantage of histone H3 lysine 4 trimethylation (H3K4me3)'s ability to mark TSSs and the recently developed ChIP-Seq and ...
ORGANISM(S): Macaca mulatta 
2010-10-18 | E-GEOD-24538 | biostudies-arrayexpress
Sort   by:  
 Page size