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ProteomicsClinical characterization and proteomic profiling of lean nonalcoholic fatty liver disease
To investigate the proteomic features in lean subjects with NAFLD, and to identify possible plasma proteins that provide potential application for diagnosing of NAFLD in lean individuals. Participants with or without NAFLD were divided into an overweight NAFLD group, an overweight control group, a l...
ORGANISM(S): Homo Sapiens 
2022-07-21 | PXD035514 |
ProteomicsLISS enables immune evasion of colorectal cancers irrespective of MSI status
LISS enables immune evasion of colorectal cancers irrespective of MSI status
ORGANISM(S): Homo Sapiens 
2026-05-25 | PXD078805 |
Metabolomics4-Octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune response gene 1 (IRG1), has excellent potential to link immunity and metabolism in activated macrophages through alkylation or competitive inhibition of target proteins. In support of this, our previous study de...

2023-01-15 | MTBLS5877 | MetaboLights
ProteomicsVirus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape
Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape
ORGANISM(S): Mus Musculus 
2023-08-10 | PXD044507 |
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicsChronotoxici-plate Containing Rhythmic Liver Organoids for Drug Screening
The circadian clock coordinates the daily rhythmicity of biological processes, and its dysregulation is associated with various human diseases. Despite the direct targeting of rhythmic genes by many best-selling and WHO essential drugs, traditional approaches can’t satisfy the need of explore multi-...
ORGANISM(S): Mus Musculus 
2023-06-25 | PXD043268 |
ProteomicsHSP60-mediated UPRmt overactivation drives triptolide-induced Hepatocellular lipoapoptosis
This study aims to investigate the role of excessive activation of the mitochondrial unfolded protein response (UPRmt) in TP-induced liver injury and to elucidate the mechanism by which HSP60 mediates this process in regulating lipid metabolism disorders.
ORGANISM(S): Mus Musculus 
2026-01-08 | PXD072797 |
ProteomicsArginine GlcNAcylation of Rab small GTPases by the pathogen Salmonella Typhimurium
We determined the GlcNAcyaltion of Rab1 by a Salmonella T3SS effector SseK3. IP experiments were performed from HEK293 cells and MS files were acquired on Q Exactive mass spectrometer. We analysed the differences of protein abundance, comparing the normalized intensity on distinct proteins from diff...
ORGANISM(S): Homo Sapiens Escherichia Coli Mus Musculus 
2020-06-05 | PXD019062 |
ProteomicsLactylation-stabilized NOL6 promotes colorectal cancer progression via recruiting STAMBP to deubiquitinate YY1 and upregulate MYC transcription
Colorectal cancer (CRC) represents a significant menace to human health, but its molecular pathogenesis remains unclear. Herein, we explored the functional role of Spindle and Nucleolar Protein 6 (NOL6) in CRC progression. In this study, we found NOL6 was significantly overexpressed in CRC tissues, ...
ORGANISM(S): Homo Sapiens 
2025-10-22 | PXD069802 |
ProteomicsEndothelial FGF13 impairs angiogenesis by accelerating oxygen-independent HIF-1α degradation
Anti-Flag antibody was added to the lysate of HUVECs transfected with Flag-FGF13 for co-immunoprecipitation, and IgG was used as a negative control. LC-MS/MS analysis was carried out by PTM Bio Co., Ltd (Zhejiang, China). The substrate proteins that may bind to FGF13 were screened out according to t...
ORGANISM(S): Homo Sapiens 
2026-06-16 | PXD079802 |
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