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TranscriptomicsA Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-derived Human Breast Cancer Xenografts
Translational breast cancer research is hampered by difficulties in obtaining and studying primary human breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology accurately. In an effort to overcome these limitations, we propagated a cohort of human breast tumo...
ORGANISM(S): Homo sapiens 
2013-06-25 | E-GEOD-34412 | biostudies-arrayexpress
ProteomicsPhysiological and proteomic changes in soft wheat seeds during accelerated aging
Wheat (Triticum aestivum L.), one of the most important crops in the world, is a staple food used for making flour, noodles, alcoholic beverages, biofuel and a variety of other products. In wheat, kernel texture and biochemical composition vary with different hardnesses. Previous study of our resear...
ORGANISM(S): Triticum aestivum (Wheat) 
2018-10-08 | PXD009156 | Pride
Tandem mass tag Differentially expressed proteins Wheat Lc-ms/ms 
ProteomicsLysine lactylation of mouse ischemia reperfusion heart
We analyzed the lactylomes and proteomes of infarcted myocardium in mice subjected to sham treatment, myocardial infarction (MI) for 30 min or MI followed by I/R for 6 h using liquid chromatography-tandem mass spectrometry (LC–MS/MS) system.
ORGANISM(S): Mus musculus (Mouse) 
2024-11-20 | PXD046631 | Pride
Heart Mouse Lysine lactylation 
ProteomicsTumor necrosis factor α-induced protein 1 as a novel tumor suppressor through selective downregulation of CSNK2B blocks Nuclear Factor-κB activation in hepatocellular carcinoma
Background: Tumor necrosis factor α-induced protein 1 (TNFAIP1) is frequently downregulated in cancer cell lines and promotes cancer cell apoptosis. However, its role, clinical significance and molecular mechanisms in hepatocellular carcinoma (HCC) are unknown. Methods: The expression of TNFAIP1 in...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD016378 | Pride
Protein kinase casein kinase ii beta Hepatocellular carcinoma Nuclear factor-κb Tumor suppressor Tumor necrosis factor α-induced protein 1 
MetabolomicsBacillus subtilis inhibits African swine fever virus infection in vivo and in vitro based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II

African swine fever virus (ASFV) is an infectious disease with a mortality rate of nearly 100% in pigs; however, no safe commercial vaccines or antiviral drugs are currently available, which seriously threatens the global pig industry. Therefore, effective biologicals against ASFV are urgently ne...

2023-11-01 | MTBLS6586 | MetaboLights
UnknownGene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data.
Not available
S-EPMC7536825 | biostudies-literature
ProteomicsPlasma proteomics analysis of inherited thrombocytopenia 2 patients
Inherited thrombocytopenia 2 (THC2) is difficult to diagnose due to the lack of specific clinical characteristics and diagnostic methods. To identify potential plasma protein biomarkers for THC2, we collected the plasma samples from THC2 patients, and analyzed the protein profiles using the liquid c...
ORGANISM(S): Homo Sapiens 
2021-03-22 | PXD024895 |
ProteomicsNovel molecular glue degraders against broad range of myeloma and lymphoma cancer cell lines
Targeted protein degradation of neosubstrates plays a crucial role in treating hematological cancers with IMiDs therapy. However, the inevitable drug resistance and hematological toxicities remain persistent challenges, limiting their clinical efficacy. Herein, we present the discovery of a lead deg...
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053334 |
ProteomicsIn-depth Serum Proteomics in Psoriasis reveals novel biomarkers for disease activity and response to Traditional Chinese Medicine
demonstrate the clinical utility of our in-depth serum proteomics platform to identify specific diagnostic and predictive biomarkers for psoriasis, suggesting a great potential for application in translation studies and precision medicine in psoriasis and other immune-mediated diseases
ORGANISM(S): Homo Sapiens 
2019-03-13 | PXD013089 |
UnknownMortality and Morbidity in Adults With Rheumatic Heart Disease.
Not available
S-EPMC11154374 | biostudies-literature
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