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ProteomicsSerum Disease-specific IgG Fc Glycosylation as Potential Biomarkers for Nonproliferative and Proliferative Diabetic Retinopathy Using Mass Spectrometry
The patients were enrolled and categorized into three groups according to clinical diagnosis: non-diabetic retinopathy; nonproliferative diabetic retinopathy ; and proliferative diabetic retinopathy. Gel electrophoresis was performed to separate IgG from morning fasting blood samples and polyaniline...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD057612 | Pride
Igg n-glycosylation Mass spectrometry Biomarkers. Diabetic retinopathy 
ProteomicsPhosphoproteomic profiling of Neospora caninum tachyzoites and PKG inhibitor MBP146-78 treatment
In this study, phosphorylation levels of Neospora caninum parasite (Nc1 strains) tachyzoites were compared with PKG inhibitor MBP146-78 treated and untreated, contains two replicates. Therefore, four subprojects are included in this project. Subproject IPX0011618001 is composed of the sub-dataset ge...
ORGANISM(S): Neospora Caninum 
2025-04-09 | PXD062765 |
ProteomicsPhosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway
In this study, we found that CB inhibited ICC cell proliferation and promoted cell apoptosis. By using phosphoproteomics, we found significant changes in the proteome and phosphorylome associated with DNA damage and apoptosis in response to CB treatment. Further investigations demonstrated that CB i...
ORGANISM(S): Homo Sapiens 
2022-06-20 | PXD034717 |
ProteomicsPhenotypic heterogeneity analysis of APC-mutant colon cancer by proteomics and phosphoproteomics identifies RAI14 as a key prognostic determinant
Adenomatous polyposis coli (APC) is an important tumor suppressor and most directly related to the regulation of WNT/β-catenin signaling pathway. APC mutation has been identified as an early event in more than 80% of sporadic colorectal cancers (CRCs). However, obvious prognostic differences are obs...
ORGANISM(S): Homo Sapiens 
2022-11-10 | PXD038081 |
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