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ProteomicsCBL ubiquitin ligase targets translation as a degrader E3
Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules that recruits an ubiquitin ligase (E3) and a neo-substrate into a ternary complex, enabling selective protein degradation. Despite the presence of over 600 E3s, only a handful are utilized in PROTAC application, potentially l...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Bacteria 
2026-01-19 | PXD063494 | Pride
Cbl Protac Targeted protein degradation Ubiquitin Mrna Translation Eif4e 
ProteomicsCBL ubiquitin ligase targets translation as a degrader E3 (part 2)
Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules that recruits an ubiquitin ligase (E3) and a neo-substrate into a ternary complex, enabling selective protein degradation. Despite the presence of over 600 E3s, only a handful are utilized in PROTAC application, potentially l...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD071639 | Pride
Cbl Protac Targeted protein degradation Ubiquitin Mrna Translation Eif4e 
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