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ProteomicsEvolutionary collateral sensitivity to pleuromutilins in vancomycin-resistant Enterococcus faecium
The rise of antibiotic resistance and decline of antibiotic discovery urgently calls for novel mechanistic understanding of pharmacological and evolutionary interactions between antibiotics and multidrug resistant bacteria to revitalize existing antibiotics. The evolutionary cross-resistance to anti...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2022-05-20 | PXD030906 | Pride
Collateral sensitivity，vancomycin-resistant enterococcus faecium，pleuromutilin 
UnknownPotential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept.
Not available
S-EPMC11463157 | biostudies-literature
UnknownLongissimus Dorsi Muscle Transcriptomic Analysis of Simmental and Chinese Native Cattle Differing in Meat Quality.
Not available
S-EPMC7770222 | biostudies-literature
UnknownProtein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy.
Not available
S-EPMC10061982 | biostudies-literature
ProteomicsPHGDH Arginine Methylation by PRMT1 Promotes Serine Synthesis and Represents a Therapeutic Vulnerability in Hepatocellular Carcinoma
Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Here, we found that R236 methylation of PHGDH promotes its activity and stimulates serine synthesis in hepatocellular carcinoma.
ORGANISM(S): Homo Sapiens 
2022-07-28 | PXD035061 |
ProteomicsPHGDH Arginine Methylation by PRMT1 Promotes Serine Synthesis and HCC Growth
Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Phosphoglycerate dehydrogenase (PHGDH) is the first rate-limiting enzyme in serine biosynthesis pathway. Here, we analyzed immunoprecipitated PHGDH from human HEK293T cells by liquid ch...
ORGANISM(S): Homo Sapiens 
2022-07-29 | PXD035287 |
UnknownOff-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production.
Not available
S-EPMC5692529 | biostudies-literature
Genomicsena-DATASET-BGI-18-06-2015-05:57:10:511-19 - samples
We sequenced 205 patients who were suffering NSCLC with Exome sequencing method.
EGAD00001001398 | EGA
Genomicsena-DATASET-BGI-18-06-2015-04:55:13:301-17 - samples
We sequenced 292 patients who were suffering NSCLC with Whole genome sequencing or Exome sequencing method.
EGAD00001001397 | EGA
GenomicsFrequent alterations in cytoskeleton remodeling genes in primary and metastatic Chinese lung adenocarcinomas
The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 si...
EGAS00001000982 | EGA
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