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MetabolomicsMetabolomic and Transcriptomic Profiling of Two Closely Related Species within the Genus Oldenlandia

The genus Oldenlandia encompasses numerous medicinal plants with significant pharmacological potential, yet their tissue-specific metabolic pathways and transcriptional profiles remain understudied. This study combined transcriptomic and metabolomic analyses to compare the differences in five ti...

2026-01-16 | MTBLS13314 | MetaboLights
TranscriptomicsConversion of mouse fibroblast to hepatocyte-like cells by defined factors
Plasticity of differentiated cells has been proved by nuclear transfer, induced pluripotent cells and transdifferentiation. Here we show that by transduction of 3 factors (Hnf1alpha, Gata4, and Foxa3) and p19Arf inactivation, tail-tip fibroblasts can be converted to hepatocyte-like (iHep) cells, exp...
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-23635 | biostudies-arrayexpress
TranscriptomicsDirect reprogramming of human fibroblasts to functional hepatocyte-like cells
Plasticity of differentiated cells has been proved by nuclear transfer, induced pluripotent cells and transdifferentiation. Here we show that by transduction of 3 factors (FOXA3, HNF1A and HNF4A), human fetal fibroblasts can be converted to hepatocyte-like cells (hiHep cells), expressing hepatic mar...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-42643 | biostudies-arrayexpress
ProteomicsPhosphoproteome and proteome of mouse hepatocyte maturation and human hepatic reprogramming
To identify central protein kinases that potentially promote the maturation, we chemically induced liver progenitor cells (CLiPs) from mouse hepatocytes using a previously established protocol, and profiled the phosphoproteome and proteome of freshly isolated primary mouse hepatocytes (MHs) and ALBU...
ORGANISM(S): Homo Sapiens Mus Musculus 
2022-08-05 | PXD035829 |
ProteomicsMS analysis of endogenously precipitated DDX20 protein complexes (immunoprecipitation (IP)–MS)
Protein lysates were derived from HEK293T cells and spermatogonial stem cells，and interacting proteins were “pulled-down” for analysis by gel electrophoresis and identification by mass spectrometry. An equal amount of non-specific IgG from rabbit serum (Thermos Fisher Scientific) was used as a negat...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-04-24 | PXD038171 |
ProteomicsProteomic analysis of the effects of DDX20 deletion in spermatogonia
To investigate the role of DDX20 in spermatogenesis, we generated Ddx20 flox/flox Ddx4-Cre mice to make a germ cell-specific Ddx20 knockout, and isolated spermatogonia from four-day-old mouse testes by THY1 magnetic beads. We then performed proteomic analysis using protein lysates obtained from THY1...
ORGANISM(S): Mus Musculus 
2024-04-24 | PXD038170 |
ProteomicsDeacetylation of Septin4 by NAD-dependent deacetylase SIRT2 mitigates damaging effects of hypertensive nephropathy
RATIONALE: Hypertension can lead to podocyte damage and subsequent apoptosis, eventually resulting in glomerulosclerosis. Although alleviating podocyte apoptosis has clinical significance for the treatment of hypertensive nephropathy, an effective therapeutic target has not yet been identified. The ...
ORGANISM(S): Mus Musculus 
2022-12-05 | PXD038538 |
UnknownMortality and Morbidity in Adults With Rheumatic Heart Disease.
Not available
S-EPMC11154374 | biostudies-literature
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