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ProteomicsProteome-wide analysis and functional identification of lysine β-hydroxybutyrylation in Ustilaginoidea virens
Lysine β-hydroxybutyrylation (Kbhb) is an evolutionarily conserved and widespread post-translational modification (PTM) in active gene transcription and cellular proliferation. However, its function remains unknown in phytopathogenic fungi. Here, we report a comprehensive identification of Kbhb in t...
ORGANISM(S): Ustilaginoidea virens 
2023-10-24 | PXD039304 | Pride
Lysine β-hydroxybutyrylation  post-translational modification  ustilaginoidea virens  virulence 
Proteomicsβ-Hydroxybutyrate Boosts Plant Immunity through Enhanced H3K9bhb Levels and Gene Expression Regulation
Although the functions of protein Kbhb have been widely studied in animal cells, however, the identification and functional characterization of this modification in plants remain unclear. Here, we identified 2,159 Kbhb sites on 1,128 proteins in rice flowers by Kbhb-proteomic analyses, serving as a ...
ORGANISM(S): Oryza sativa (Rice) 
2025-07-05 | PXD051126 | Pride
Lysine β-hydroxybutyrylation 
ProteomicsRedox regulation of cytosolic translation in rice during fungal infection identified by quantitative proteomics
Pathogen attack can increase plant levels of reactive oxygen species (ROS), which then act as signaling molecules activating plant defense. Elucidating these processes is crucial to understanding the redox signaling pathways in plant defense responses. By an iodo TMT–based quantitative proteomic app...
ORGANISM(S): Oryza sativa (Rice) 
2023-06-06 | PXD034430 | Pride
Ros  protein oxidation  translation  infection  immunity  rice 
ProteomicsQuantitative proteomic analysis based on the isobaric tags for relative and absolute quantitation (iTRAQ) labeling in WT and NudCL2 KO-1 HEK-293 cells
Cytokinesis is a key step in the later stage of cell division to partition cellular contents into daughter cells, which undergoes precise regulation in temporal and spatial. However, the underlying mechanisms are still unclear. Here, we show that Hsp90 cochaperone, NudCL2 (NudC-like protein 2), is r...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD043570 | Pride
Hek-293 Nudcl2 Itraq 
TranscriptomicsNext generation sequencing of Coccinella septempunctata L. with non-diapause, diapause, and diapause-terminated states
The most common ladybird beetle, Coccinella septempunctata L., is an excellent predator of crop pests such as aphids and white flies, and it shows a wide range of adaptability, a large appetite and a high reproductive ability. In this study, we collected female adults in three different states, i.e...
ORGANISM(S): Coccinella septempunctata 
2016-06-01 | E-GEOD-75645 | biostudies-arrayexpress
ProteomicsTandem mass tags (TMT)–based quantitative proteomics approach quantified in 2-hydroxyisobutyrylation site of rice spikelets and Ustilaginoidea virens by mass spectrometry.
Rice false smut, caused by the pathogenic ascomycete fungus Ustilaginoidea virens (teleomorph: Villosiclava virens), is one of the most devastating grain diseases in the majority of rice-growing areas of the world. Lysine 2-hydroxyisobutyrylation (Khib) is a novel post-translational modification (PT...
ORGANISM(S): Ustilaginoidea virens Oryza sativa (Rice) 
2023-06-06 | PXD019114 | Pride
2-hydroxyisobutyrylation  tmt  mass spectrometry 
ProteomicsDown-regulated Glutathione Peroxidase-4 by Graphene Quantum Dots Inducing Ferroptosis in Macrophages
to explore the mechanism, we analyzed the differences in the protein profile of macrophages using tandem mass tags (TMT) proteomics.
ORGANISM(S): Mus Musculus 
2020-12-23 | PXD023303 |
ProteomicsThe Dynll1-Cox4il Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species
Cellular membrane proteins are a critical part of the host defense mechanisms against infection and intracellular survival of Listeria monocytogenes. The complex spatiotemporal regulation of bacterial infection by various membrane proteins has been challenging to study. Here, using mass spectrometry...
ORGANISM(S): Mus Musculus 
2020-02-17 | PXD016452 |
ProteomicsThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5’-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK. ...
ORGANISM(S): Oryctolagus Cuniculus 
2022-08-10 | PXD035968 |
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