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MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
TranscriptomicsCharacterization of human plasma-derived exosomal RNAs
Exosomes, endosome-derived membrane microvesicles, contain a specific set of RNA transcripts that are involved in cell-cell communication and hold a great potential as disease biomarkers. To systemically characterize exosomal RNA profiles, we performed RNA sequencing analysis using three human plasm...
ORGANISM(S): Homo sapiens 
2013-05-15 | E-GEOD-45722 | biostudies-arrayexpress
ProteomicsAge-Dependent Changes in the Plasma Proteome of Healthy Adults
Human blood plasma is a complex which communicates with most parts of the body and reflects changes in the state of the organism, therefore identifying age-related biomarkers can help to predict and monitor age-related physiological decline and diseases, as well as to find new treatments for disease...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD016199 | Pride
Aging  healthy adults  plasma  proteomics  tmt-lc-ms/ms 
UnknownA J-shaped association between weight-adjusted waist index and cardiovascular disease: a longitudinal study from the CHARLS database.
Not available
S-EPMC12628520 | biostudies-literature
GenomicsIntronic Non-CG DNA Hydroxymethylation and Alternative mRNA Splicing in Honey Bees
Honey bee non-CG DNA hydroxymethylation is enriched in the introns, which supplements previous findings that honey bee CG DNA methylation is enriched in exons. Bisulfite sequencing combined with Pvu-Seq to distinguish 5-methylcytosine from 5-hydroxymethylcytosine and RNA-Seq
ORGANISM(S): Apis mellifera scutellata 
2013-09-19 | E-GEOD-50990 | biostudies-arrayexpress
TranscriptomicsMapping RNA-RNA interactome and RNA structures in vivo with MARIO
Many biological processes are regulated by RNA-RNA interactions 1, nonetheless it remains formidable to analyze the entire RNA interactome. We developed a method, MARIO (MApping Rna-rna Interactions in vivO), to map protein-assisted RNA-RNA interactions in vivo. By circumventing the selection for a ...
ORGANISM(S): Mus musculus 
2016-06-23 | E-GEOD-61489 | biostudies-arrayexpress
ProteomicsSecretomics and proteomics analysis of the Primary turmor cell and PC cells
Secretomics and proteomics analysis of the Primary turmor cell and PC cells
ORGANISM(S): Homo Sapiens 
2024-09-09 | PXD055731 |
ProteomicsCRL4AMBRA1 mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer
AMBRA1 ubiquitinates PR to ptomote progestin resistance in endometrial cancer
ORGANISM(S): Homo Sapiens 
2026-01-04 | PXD072640 |
ProteomicsCRL4AMBRA1 mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer
AMBRA1 ubiquitinates PR to ptomote progestin resistance in endometrial cancer
ORGANISM(S): Homo Sapiens 
2026-01-08 | PXD072904 |
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