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ProteomicsThe NAE1-mediated Neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells
Cells were lysed with TFA, and precipitated with cold acetone. The precipitates were transferred to E3filters and digestion was performed overnight with trypsin. The peptides were desalted with StageTips, and were analyzed on Eclipse Orbitrap with DIA mode. For MS1, the resolution was set to 120,00...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-27 | MSV000094179 | MassIVE
UnknownDeveloping and Preliminary Validating an Automatic Cell Classification System for Bone Marrow Smears: a Pilot Study.
Not available
S-EPMC7476995 | biostudies-literature
UnknownSocial asset or social liability? How partisanship moderates the relationship between social capital and Covid-19 vaccination rates across United States counties.
Not available
S-EPMC9434956 | biostudies-literature
TranscriptomicsTrivalent arsenic inhibits the functions of chaperonin complex
The goal of this study was to identify yeast mutants with arsenite hypersensitivity. Keywords: dose response Matched pools of yeast knockout (YKO) mutants were grown in paired growth media lacking or containing arsenite at various concentrations. The relative abundances of the YKO mutants were profi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-26 | E-GEOD-5973 | biostudies-arrayexpress
ProteomicsIdentification of small open reading frames-encoded peptides in Saccharomyces cerevisiae under different stress conditions
Here we used mass spectrometry-based proteomics technology to explore SEPs with potential cellular stress function in Saccharomyces cerevisiae. Microproteins with unique peptides were identified under six culture conditions: normal, oxidation, starvation, UV radiation, heat shock, and heat shock wit...
ORGANISM(S): Saccharomyces Cerevisiae 
PXD028623 |
ProteomicsProteomics data for: Pan-Apoptotic Protein Signature as a Novel Diagnostic and Prognostic Biomarker for Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) remains a major cause of morbidity and mortality, with no rapid blood-based biomarkers available to assess secondary brain injury. This study aimed to identify a circulating pan-cell death protein signature for diagnosing and prognosing ICH. We prospectively enrolled 6...
ORGANISM(S): Homo Sapiens 
2025-12-11 | PXD071856 |
ProteomicsA proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
KRAS mutant cancers, which feature the activation of multiple phosphorylation signaling pathways, remain a major challenge for cancer therapy. This study provides a landscape of the proteomics and phosphoproteomics of KRAS mutant cancers by analyzing different KRAS mutant human cancer cell lines acr...
ORGANISM(S): Homo Sapiens 
2021-06-23 | PXD026892 |
ProteomicsTargeting Histone Modification Crosstalk as a Therapeutic Strategy for EZH2-aberrant Solid Tumors
Mutations or aberrant upregulation of the histone methyltransferase EZH2 occur frequently in human cancers yet EZH2-targeted therapies have only shown very limited clinical benefits in hematological malignancies. We report here that upon EZH2 inhibition, MLL1 interacts with p300/CBP complex that dir...
ORGANISM(S): Homo Sapiens 
PXD010842 |
ProteomicsGlobal identification ofphospho-dependent SCF ubiquitin ligase substrate reveal a role of ERK-FBXO22-BAG3 axis in tumorigenesis
293T cells were cultured in SILAC medium. Heavy group was labeled with K6&R10. Light group was labeled with K0&R0. In light group, cells were treated with MLN4924. In heavy group, cells were treated with DMSO. Then cells were lysed, mixed and tryptic digested. Peptide mixture was subjected to phosph...
ORGANISM(S): Homo Sapiens 
PXD027020 |
ProteomicsA Recombinant Vaccine Targeting Receptor-binding Domain of SARS-CoV-2 Spike Protein Induces Protective Immunity in Mice and Non-human Primates
The novel Coronavirus SARS-CoV-2 causes a respiratory illness called COVID-19 leading to a pandemic. An effective preventive vaccine against this virus is urgently needed.
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
PXD020653 |
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