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TranscriptomicsLEF1 in Burkitt lymphoma
Recently global gene expression profiling of patients samples lead to a molecular definition of Burkitt Lymphoma (BL) with lymphocyte enhancer-binding factor 1 (LEF1) as a signature gene. Here we report the discovery of nucleic LEF1 in a very high proportion of BL cases (15/18) and LEF1 target genes...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-42637 | biostudies-arrayexpress
ProteomicsPlatform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue
10 µm formalin-fixed paraffin-embedded tissue sections were deparaffinized with xylene; homogenization was performed in lysis-buffer (20 mM Tris-HCl, pH 8.8, 200 mM glycine, 200 mM DTT, 4% SDS)in an ultrasonic bath; samples were incubated under continuous agitation first at 99 °C for 30 min, then a...
ORGANISM(S): Homo sapiens (Human) 
2020-05-18 | PXD012317 | Pride
Lymphoma Dlbcl Proteomics Swath-ms Cell of origin 
TranscriptomicsAnalyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models
Understanding the structure and interplay of cellular signalling pathways is one of the great challenges in molecular biology. Boolean Networks can infer signalling networks from observations of protein activation. In situations where it is difficult to assess protein activation directly, Nested Eff...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-68761 | biostudies-arrayexpress
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