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MetabolomicsImproving global feature detectabilities through scan range splitting for untargeted metabolomics by high-performance liquid chromatography-Orbitrap mass spectrometry
Untargeted metabolomics aims at obtaining quantitative information on the highest possible number of low-molecular biomolecules present in a biological sample. Rather small changes in mass spectrometric spectrum acquisition parameters may have a significant influence on the detectabilities of metabo...
2016-06-09 | MTBLS233 | MetaboLights
TranscriptomicsRNAi profiling by array of human U-2-OS osteosarcoma cells with knockdown of Asf1a and Asf1b
We used RNAi to knock-down the two isoforms of Asf1, Asf1a and Asf1b, in human U-2-OS osteosarcoma cells. We obtained two replicates each with siRNAs against Asf1a, Asf1b, combined siRNAs against both isoforms, and two control samples. For these samples, we measured genome-wide transcription levels ...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-MEXP-2671 | biostudies-arrayexpress
TranscriptomicsComprehensive proteomic and transcriptomic characterization of hepatic expression signatures affected in p14 liver conditional knockout mice
Scaffold proteins regulate intracellular MAP kinase signaling by providing critical spatial and temporal specificity. We have shown previously that the scaffold protein MEK1 partner (MP1) is localized to late endosomes by the adaptor protein p14. Using conditional gene disruption of p14 in livers of...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-24461 | biostudies-arrayexpress
ProteomicsThe endosomal proteome of LAMTOR2-deficient primary macrophages
A quantitative iTRAQ-based organelle proteomics analysis of endosomes derived from LAMTOR2-deficient macrophages has been performed. Primary macrophages were derived from bone marrow of conditional knockout mice carrying a specific deletion of LAMTOR2 in the monocyte/macrophage cell lineage. The com...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-26 | PXD009148 | Pride
Macrophages Ragulator Organelle proteomics Lamtor Foam cells 
UnknownMammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks.
Not available
S-EPMC5179496 | biostudies-literature
UnknownB-Lines Scores Derived From Lung Ultrasound Provide Accurate Prediction of Extravascular Lung Water Index: An Observational Study in Critically Ill Patients.
Not available
S-EPMC8609506 | biostudies-literature
UnknownSurvey of ex vivo drug combination effects in chronic lymphocytic leukemia reveals synergistic drug effects and genetic dependencies.
Not available
S-EPMC7584477 | biostudies-literature
GenomicsHuman variation in PolII and NF-KappaB binding (ChIP-seq study with Pol II)
We examined genome-wide variation in transcription factor binding in different individuals and a chimpanzee using chromatin immunoprecipitation followed by massively-parallel sequencing (ChIP-Seq). The binding sites of RNA Polymerase II (Pol II) as well as a key regulator of immune responses, NFkB, ...
ORGANISM(S): Pan troglodytes 
2010-03-22 | E-GEOD-19484 | biostudies-arrayexpress
GenomicsHuman variation in PolII and NF-KappaB binding (ChIP-seq study with NF-KappaB)
We examined genome-wide variation in transcription factor binding in different individuals and a chimpanzee using chromatin immunoprecipitation followed by massively-parallel sequencing (ChIP-Seq). The binding sites of RNA Polymerase II (Pol II) as well as a key regulator of immune responses, NFkB, ...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19485 | biostudies-arrayexpress
TranscriptomicsHuman variation in PolII and NF-KappaB binding (RNA-seq study with TNF-alpha induced)
We examined genome-wide variation in transcription factor binding in different individuals and a chimpanzee using chromatin immunoprecipitation followed by massively-parallel sequencing (ChIP-Seq). The binding sites of RNA Polymerase II (Pol II) as well as a key regulator of immune responses, NFkB, ...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19481 | biostudies-arrayexpress
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