Sort   by:  
 Page size 
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsGene expression profiles of MBP-specific T cells during experimental autoimmune encephalomyelitis
2nd generation sequencing was used to compare expression profiles of MBP-specific T cells retrieved from blood, CSF, spinal cord meninges and parenchyma. The overall expression profiles were found to be very similar.However, genes regulated during T cell activation were found to be upregulated in T ...
ORGANISM(S): Rattus norvegicus 
2016-02-12 | E-GEOD-75488 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression analysis of T-cell prolymphocytic leukemia (T-PLL) patient samples
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells with an urgent need for rationally designed therapies to address its notoriously chemo-refractory behavior. To characterize the gene expression profiles, 12 T-PLL MNC samples (>90% tumor cell content) were scr...
ORGANISM(S): Homo sapiens 
2017-09-08 | E-MTAB-5916 | biostudies-arrayexpress
TranscriptomicsSingle-cell Atlas of intrahepatic T cells reveals a population of liver-resident naive-like CD4+ T cells expanded in primary sclerosing cholangitis
The composition of intrahepatic immune cells in primary sclerosing cholangitis (PSC) and their contribution to disease pathogenesis is widely unknown. We here generated a single-cell atlas of intrahepatic T cells in PSC, a type of immune cells that has previously been involved in the pathogenesis of...
ORGANISM(S): Homo sapiens 
2021-03-27 | E-MTAB-10143 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of human naive CD4 T cells identifies miR-34c-5p as a novel regulator of T cell activation and HIV replication
Cell activation is a vital step for T cell memory/effector differentiation as well as for productive HIV infection. To identify novel regulators of this process, we used next generation sequencing to profile changes in microRNA expression occurring in purified human naive CD4 T cells in response to ...
ORGANISM(S): Homo sapiens 
2016-12-21 | E-MTAB-4214 | biostudies-arrayexpress
TranscriptomicsCoexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
CD4(+) type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in promoting and maintaining tolerance. The absence of surface markers that uniquely identify Tr1 cells has limited their study and clinical applications. By gene expression profiling of human Tr1 cell clones...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-53514 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of CD4+myelin basic protein specific T cells
CNS autoimmunity is induced by autoreactive T cells reactive against CNS antigen. However how these T cells become able to transgress the blood brain barrier is not CNS autoimmunity is induced by autoreactive T cells reactive against CNS antigen. Here a gene expression profile of the pathogenic T ...
ORGANISM(S): Rattus norvegicus 
2012-08-23 | E-GEOD-38645 | biostudies-arrayexpress
ProteomicsMetabolic Reprogramming Driven by Ant2 Deficiency Augments T Cell Function and Anti-Tumor Immunity
cell activation demands a significant boost in NAD+ levels, often outpacing the capacity of oxidative phosphorylation (OXPHOS). To explore how T cells manage this metabolic stress, we created T cell-specific ADP/ATP translocase-2 knockout (Ant2-/-) mice. Ant2, which is vital for ADP/ATP exchange bet...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-09 | PXD062646 | Pride
Naive t cells Mouse Ant2ko Spleen 
TranscriptomicsThe Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses
T-bet is a critical transcription factor for T helper 1 (Th1) cell differentiation. To study the regulation and functions of T-bet, we developed a T-bet-ZsGreen reporter mouse strain, in which GFP faithfully reflects the expression of T-bet. By using this tool, we report that signals elicited by IL...
ORGANISM(S): Mus musculus 
2012-10-04 | E-GEOD-38808 | biostudies-arrayexpress
TranscriptomicsExpression Data from BALB/c and Stat6-deficient bone marrow derived macrophages (BMDM)
We used microarrays to find Stat6 dependent genes in control and IL-4 exposed bone marrow derived macrophages. Alternatively activated macrophages (AAM) accumulate in tissues during Th2-associated immune responses like helminth infections and allergic disorders. These cells possess potent inhibitor...
ORGANISM(S): Mus musculus 
2010-07-19 | E-GEOD-20030 | biostudies-arrayexpress
Sort   by:  
 Page size