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UnknownKL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.
Not available
S-EPMC8219708 | biostudies-literature
UnknownAssessing cellular response to functionalized α-helical peptide hydrogels.
Not available
S-EPMC4276410 | biostudies-literature
TranscriptomicsGene expression in response to genetic and chemical perturbations of chromatin structure
Microarray expression profiling was used to identify genes expressed misexpressed in wild-type Arabidopsis seedlings treated with 5-aza-2’ deoxyctidine (5AC) or trichostatin A (TSA), and in decrease in dna methylation1 (ddm1) mutant seedlings. 10 day-old Arabidopsis seedlings (ecotype Ws) were grown...
ORGANISM(S): Arabidopsis thaliana 
2011-06-03 | E-GEOD-25067 | biostudies-arrayexpress
TranscriptomicsOrgan-specific light-responsive gene expression profiling assay using 18kA and 18kB soybean cDNA microarrays
An expression profiling assay comparing dark-grown soybean seedlings with seedlings treated with 1 h far-red light using different organs including cotyledons, hook, and hypocotyl with the soybean cDNA 18kA and 18kB microarray. pairwise comparisons of far-red light treated samples and dark-grown sam...
ORGANISM(S): Glycine max 
2011-07-06 | E-GEOD-30408 | biostudies-arrayexpress
TranscriptomicsGenome-wide maps of Usp16, ubH2A and gene expression profiles in wild type and Usp16 knock out mouse embryonic stem cells (ESCs) and embryoid bodies (EBs)
Polycomb Repressive Complex 1 and histone H2A ubiquitination (ubH2A) contribute to embryonic stem cell (ESC) pluripotency by repressing lineage-specific gene expression. However, whether active deubiquitination co-regulates ubH2A levels in ESCs and during differentiation is not known. Here, we repor...
ORGANISM(S): Mus musculus 
2014-05-02 | E-GEOD-52899 | biostudies-arrayexpress
TranscriptomicsKras mutant v WT with or without AZD6244 in vivo study
HCT116 (kRas mt) cells and HKH2 (Kras wt) cells were implanted into the right and left flanks of nude mice and either untreated or treated with a MEK inhibitor (AZD6244) over time. Tumours were excised and harvested for RNA extraction at the end of the experiment and hybridised to the Colorectal DS...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-MEXP-3557 | biostudies-arrayexpress
TranscriptomicsRNA-seq alignment to individualized genomes
The source of most errors in RNA sequencing (RNA-seq) read alignment is in the repetitive structure of the genome and not with the alignment algorithm. Genetic variation away from the reference sequence exacerbates this problem causing reads to be assigned to the wrong location. We developed a metho...
ORGANISM(S): Mus musculus 
2014-06-10 | E-GEOD-45684 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic fibroblasts expressing wild type and heterozygous Plk4
A microarray comparison was performed to identify genes over expressed in both wild type and heterozygous Plk4 MEFs
ORGANISM(S): Mus musculus 
2009-09-03 | E-MEXP-2161 | biostudies-arrayexpress
GenomicsGenome-wide analysis of histone modifications in latently HIV-1 infected T cells
The epigenetic mechanisms established by histone modifications may affect the transcriptional silencing of HIV-1 and viral latency. A systematic epigenome profiling could be applicable to develop new epigenetic diagnostic markers for detecting HIV-1 latency. In this study, histone modification prof...
ORGANISM(S): Homo sapiens 
2014-06-06 | E-GEOD-58247 | biostudies-arrayexpress
TranscriptomicsMolecular Profiles of Human Breast Cancer and Their Association with Tumor Subtypes and Disease Prognosis (Illumina)
This study identified DNA methylation patterns that were associated with tumor subtypes, disease outcome, and distinct metabolome and gene expression patterns. This study performed a large scale DNA methylation (Illumina HumanMethylation450 BeadChip [HumanMethylation450 15017482 v.1.1], N=72), gene ...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-37754 | biostudies-arrayexpress
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