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TranscriptomicsMicroarray analysis of beta-catenin regulated target genes in SW480 colon cancer cells
Deregulation of the canonical Wnt/beta-catenin pathway is one of the earliest events in the pathogenesis of colon cancer. Mutations in APC or CTNNB1 are frequent in colon cancer and cause aberrant stabilization of beta-catenin, which activates Wnt target genes by binding to chromatin via TCF/LEF tra...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-53656 | biostudies-arrayexpress
MetabolomicsClock regulation of metabolites reveals coupling between transcription and metabolism
The circadian clock is intricately connected with metabolism, however the precise details of these connections are incomplete. Here we used high temporal resolution metabolite profiling to determine circadian regulation of mouse liver and cell autonomous metabolism. In mouse liver, we found ~50% of ...
2017-04-05 | MTBLS292 | MetaboLights
TranscriptomicsHigh resolution temporal profiling of gene expression during Arabidopsis leaf development (senescence process)
Leaf senescence is an essential developmental process that involves altered regulation of thousands of genes and changes in many metabolic and signaling pathways resulting in massive physiological and structural changes in the leaf. The regulation of senescence is complex and although several senesc...
ORGANISM(S): Arabidopsis thaliana 
2011-03-24 | E-GEOD-22982 | biostudies-arrayexpress
TranscriptomicsmiR-122 as a Regulator of Mitochondrial Metabolic Gene Network in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, reflecting the need for a better understanding of hepatocarcinogenesis. In this study, we examined the genome-wide expression profiles of both miRNAs and mRNAs from paired tumor and adjacent non-tumor tissues fro...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22058 | biostudies-arrayexpress
UnknownWhole genome sequence analyses of brain imaging measures in the Framingham Study.
Not available
S-EPMC5772158 | biostudies-literature
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