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TranscriptomicsDifferential expression of 24,426 human alternative splicing events and predicted cis-regulation in 48 tissues
Alternative pre-messenger RNA splicing impacts development, physiology, and disease, but its regulation in humans is not well understood, partially due to the limited scale to which the expression of specific splicing events has been measured. We generated the first genome-scale expression compendi...
ORGANISM(S): Homo sapiens 
2008-08-15 | E-GEOD-11863 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prostate cancer cells with arachidonic acid reveals induction of 11 genes that are regulated by NFkappaB
Essential fatty acids (FA) are not only energy-rich molecules; they are also an important component of the membrane bilayer and recently have been implicated in induction of fatty acid synthase (FAS) and other genes. Using gene chip analysis, we have found that arachidonic acid (AA), an omega-6 fat...
ORGANISM(S): Homo sapiens 
2007-07-03 | E-GEOD-3737 | biostudies-arrayexpress
TranscriptomicsTemporal pattern of skeletal muscle gene expression following endurance exercise in Alaskan sled dogs
Background: Muscle responses to exercise are complex, and potentially include acute responses to exercise-induced injury as well as longer-term adaptive training responses. Using Alaskan sled dogs as an experimental model, changes in muscle gene expression were analyzed to better understand the tem...
ORGANISM(S): Canis lupus familiaris 
2010-05-16 | E-GEOD-15117 | biostudies-arrayexpress
UnknownClonally expanded HIV-1 proviruses with 5'-leader defects can give rise to nonsuppressible residual viremia.
Not available
S-EPMC10014112 | biostudies-literature
UnknownMolecular characterization of pigmented and nonpigmented isolates of Mycobacterium avium subsp. paratuberculosis.
Not available
S-EPMC130953 | biostudies-literature
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
UnknownMutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans.
Not available
S-EPMC11734625 | biostudies-literature
TranscriptomicsObesity study in transgenic and knockout animals
A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our m...
ORGANISM(S): Mus musculus 
2009-03-07 | E-GEOD-12000 | biostudies-arrayexpress
ProteomicsProteomics of brain from a myeloid specific NPC1 KO mouse
Niemann-Pick type C (NPC) disease is an inherited lysosomal storage disorder mainly driven by mutations in NPC1 gene, causing lipid accumulation within late endosomes/lysosomes, and resulting in progressive neurodegeneration. Although microglial activation proceeds neuronal loss, it remains elusive ...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-05 | PXD056188 | Pride
Cerebrum Brain Npc1 Cerebellum Mouse Microglia Niemann-pick disease type c 
UnknownCRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.
Not available
S-EPMC8956604 | biostudies-literature
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