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TranscriptomicsExpression data from WT and TCF-1-deficient memory CD8 T cells
TCF-1 is an HMG family transcription factor which is known to be activated by the canonical Wnt signaling pathway and modulated by other signals such as those derived from T cell receptor. We found that during CD8 T cell responses, TCF-1 deficiency impaired long-term maintenance of antigen-specific ...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-20754 | biostudies-arrayexpress
TranscriptomicsWhole-genome microarray analysis of primary, secondary, tertiary and quaternary memory CD8 T cells
The transcriptome of naive OT-I T cells was compared to memory CD8 T cells after 1, 2, 3, or 4 infection with ovalbumin expressing Listeria monocytogenes (LM-OVA). Naive Thy1.1 OT-I T cells were adoptively transferred into Thy1.2 naive hosts prior to infection with LM-OVA. The resulting memory CD8 T...
ORGANISM(S): Mus musculus 
2010-07-09 | E-GEOD-21360 | biostudies-arrayexpress
TranscriptomicsExpression data from WT DN3, TCF-1-deficient DN3 thymocytes, and T cell lymphomas in TCF-1-deficient animals.
TCF-1 is an HMG family transcription factor which is known to be critical for T cell development. We discovered that it has a unique role in suppressing malignant transformation of developing thymocytes at early stages. We identified ID2 and LEF-1 as key TCF-1 target genens in tumor suppression. We ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-33292 | biostudies-arrayexpress
TranscriptomicsA validated gene regulatory network and GWAS identifies early regulators of T-cell associated diseases (exon array)
In this work we present an analytical strategy to systematically identify early regulators by combining gene regulatory networks (GRN) with GWAS. We hypothesized that early regulators in T-cell associated diseases could be found by defining upstream transcription factors (TFs) in T-cell differentia...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-60677 | biostudies-arrayexpress
TranscriptomicsA validated gene regulatory network and GWAS identifies early regulators of T-cell associated diseases (Th17 Treg)
In this work we present an analytical strategy to systematically identify early regulators by combining gene regulatory networks (GRN) with GWAS. We hypothesized that early regulators in T-cell associated diseases could be found by defining upstream transcription factors (TFs) in T-cell differentia...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-60679 | biostudies-arrayexpress
TranscriptomicsA validated gene regulatory network and GWAS identifies early regulators of T-cell associated diseases (Th1 Th2)
In this work we present an analytical strategy to systematically identify early regulators by combining gene regulatory networks (GRN) with GWAS. We hypothesized that early regulators in T-cell associated diseases could be found by defining upstream transcription factors (TFs) in T-cell differentia...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-60678 | biostudies-arrayexpress
TranscriptomicsA validated gene regulatory network and GWAS identifies early regulators of T-cell associated diseases [MAF siRNA]
In this work we present an analytical strategy to systematically identify early regulators by combining gene regulatory networks (GRN) with GWAS. We hypothesized that early regulators in T-cell associated diseases could be found by defining upstream transcription factors (TFs) in T-cell differentia...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-61964 | biostudies-arrayexpress
ProteomicsSite-specific Extraction of O-linked glycopeptides (EXoO) Maps Landscape of In Vivo O-linked Glycoproteome
Protein glycosylation is one of the most common protein modifications and plays essential roles in biology and therapeutics. However, the analysis of in vivo O-linked glycosylation, a major type of protein glycosylation, has been severely impeded by the scarcity of technology. Here, a chemoenzymatic...
ORGANISM(S): Homo sapiens (Human) 
2018-12-05 | PXD009476 | Pride
Site-specific Glycosylation Exoo In vivo O-linked 
UnknownOutcomes after thrombus aspiration for ST elevation myocardial infarction: 1-year follow-up of the prospective randomised TOTAL trial.
Not available
S-EPMC5007127 | biostudies-literature
TranscriptomicsExon Level Expression Profiling: a Novel Unbiased Transcriptome Analysis for Body Fluids
Transcriptome analysis of partially degraded and fragmented RNA samples from body fluids Global gene expression profiling has shown great promise in high-throughput biomarker discovery for early disease detection in body fluids such as saliva, which is accessible, cost-effective, and non-invasive. ...
ORGANISM(S): Homo sapiens 
2008-05-19 | E-GEOD-7760 | biostudies-arrayexpress
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