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ProteomicsDelta-cleavage verification in recombinant human APP
LC-MS/MS analysis of recombinant APP preparations treated with PDAPP/KO brain to document the cleavage of APP by delta-secretase.
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD067552 | Pride
Human app Sorcs2 
TranscriptomicsComparative transcriptome profiling of Amyloid Precursor Protein APP family members in the adult cortex
The β-amyloid precursor protein APP and the related APLPs, undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer disease (AD), the physiological role of APP family members and their diverse pr...
ORGANISM(S): Mus musculus 
2011-03-18 | E-GEOD-25926 | biostudies-arrayexpress
TranscriptomicsChanges in gene expression induced by apple polyphenol (APP)
γδ T cells are lymphocytes that function in both innate and adaptive immune responses, and our laboratory has previously reported that both bovine and human γδ T cells are primed for secondary responses by tannin components of the unripe apple peel (APP). In this report we began to investigate the ...
ORGANISM(S): Bos taurus 
2010-08-10 | E-GEOD-13321 | biostudies-arrayexpress
TranscriptomicsmiRNA sequencing of exosomes derived from N2A and APP-N2A cells
APP misexpression plays a crucial role in triggering a complex pathological cascade, leading to Alzheimer’s disease (AD). The aim of this study is for determine the influence of APP ectopic expression on the miRNA profiles of neuronal exosomes. In study, miRNA sequencing was done using the exosomes ...
ORGANISM(S): Homo sapiens 
2022-03-30 | E-MTAB-11106 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse APP transgenic mouse model of Alzheimers disease treated with BDNF
We examined transgenic (TG) mice expressing human APP695 bearing the double Swedish (671KM>NL) and Indiana (717V>F) amyloid precursor protein (APP) mutations. Lentiviral vectors constitutively expressing BDNF-GFP under control of the CMV/ß-actin hybrid promoter or GFP alone were injected into the e...
ORGANISM(S): Mus musculus 
2009-02-01 | E-GEOD-14499 | biostudies-arrayexpress
GenomicsChIP-seq experiment in J20 hAPP mice and Pilocarpine-treated mice using deltaFosB antibody against whole-hippocampal lysate
∆FosB epigenetically regulates target gene expression; however, whether ∆FosB targets the same genes when induced by recurrent seizures in different neurological conditions like Alzheimer's disease (AD) is unclear. We performed hippocampal ChIP-sequencing to identify ∆FosB target genes in APP mice, ...
ORGANISM(S): Mus musculus 
2020-04-16 | E-MTAB-8954 | biostudies-arrayexpress
TranscriptomicsSmall-RNA high-throughput sequencing of head-and-neck cancer with or without human papilloma virus etiology
HPV positive head and neck cancer (HNC) are thought to have different etiology from HPV-unrelated HNC. There are indications that HPV positive HNC have better survival and that treatment options could be optimized in this set of tumours. In this study, we sought to evaluate miRNA profiles in the dif...
ORGANISM(S): Homo sapiens 
2019-02-20 | E-MTAB-7030 | biostudies-arrayexpress
ProteomicsHuman CSF peptidomics of gamma secretase inhibition
Fifteen human healthy volunteers, divided into three groups, received a single dose of placebo or either 140 mg or 280 mg of the ?-secretase inhibitor semagacestat (LY450139). Endogenous peptides in CSF, sampled prior to administration of the drug and at six subsequent time points, were analyzed by ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080870 | MassIVE
TranscriptomicsTranscription profiling of human SHEP-SF cells expressing AICD and Fe65
The amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimerâ??s disease (AD). Processing of APP by β- and γ-secretase activities results in the production of Ã?-amyloid (AÃ?), the main constituent of Alzheimer plaques, but also in the generation of the APP intracellul...
ORGANISM(S): Homo sapiens 
2007-06-22 | E-GEOD-4097 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse vehicle and sAPPalpha-treated hippocampal slice cultures
Gene expression changes induced by alpha-secretase cleaved amyloid precursor protein (sAPPalpha) in organotypic hippocampal slice cultures of male, postnatal day 15 mice (C57B6/SJL). Hippocampal slice cultures were treated with phosphate buffered saline (GSM26700, GSM26701, GSM26702) or 1 nM sAPPal...
ORGANISM(S): Mus musculus 
2007-10-10 | E-GEOD-1555 | biostudies-arrayexpress
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