Sorcs2 - OmicsDI

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1 Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17 177 Stockholm, Sweden 2 Chemical Proteomics Unit, Science for Life Laboratory (SciLifeLab), SE-17 177 Stockholm, Sweden 3 Chemical Proteomics, Swedish National Infrastructure for Biological Mass Spectrometry (BioMS), SE-17 177 Stockholm, Sweden (1)
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Tags

xref:PubMed:37842085 (2)
xref:PubMed:38226160 (1)
xref:PubMed:36996265 (1)
xref:PubMed:40588680 (1)

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Sorting receptor SORCS2 facilitates a protective stress response in pancreatic islets

PRJNA966904 | ENA

SorCS2 controls Wnt signaling homeostasis during neurodevelopment by regulating Ror2 activity and trafficking

Wnt signaling orchestrates key developmental processes, yet mechanisms restricting its spatial and temporal activity remain incompletely understood. Here we identify SorCS2, a VPS10p-domain sorting receptor, as a conserved regulator of Wnt signaling homeostasis. Integrating proteomics, cell biology,...

ORGANISM(S): Mus musculus (Mouse)

2026-10-02 | PXD085067 | Pride

Sorting receptor SORCS2 facilitates a protective stress response in pancreatic islets

Objective: SORCS2 is an intracellular sorting receptor genetically associated with body mass index (BMI) in humans, yet its mode of action remains unknown. Elucidating the receptor function that defines its role in metabolic health is the objective of this work. Methods: Combining in vivo metabolic ...

ORGANISM(S): Mus musculus

2023-05-10 | GSE231551 | GEO

Structural insights into SorCS2-Nerve Growth Factor complex formation.

Not available

S-EPMC6065357 | biostudies-literature

SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease.

Not available

S-EPMC5414556 | biostudies-literature

Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.

Not available

S-EPMC6317871 | biostudies-literature

Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks.