Ror2 - OmicsDI

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Study type

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Lab affiliation

1 Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17 177 Stockholm, Sweden 2 Chemical Proteomics Unit, Science for Life Laboratory (SciLifeLab), SE-17 177 Stockholm, Sweden 3 Chemical Proteomics, Swedish National Infrastructure for Biological Mass Spectrometry (BioMS), SE-17 177 Stockholm, Sweden (1)
Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver V5Z 1L3, Canada. (1)
Children's Hospital of Philadelphia (1)
Proteomics Unit (UCCTs), Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain (1)
Tianjin Medical University General Hospital (1)

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ROR2 drives right ventricular heart failure via disruption of proteostasis

This study assessed the impact of ROR2 expression on the global proteome using neonatal rat ventricular myocytes (NRVMs) using adenovirus to overexpress ROR2 vs control NRVMs with and without MG132 to block the proteasome to characterize proteasome-mediated clearance.

ORGANISM(S): Rattus norvegicus (Rat)

2026-04-28 | PXD056556 | Pride

SorCS2 controls Wnt signaling homeostasis during neurodevelopment by regulating Ror2 activity and trafficking

Wnt signaling orchestrates key developmental processes, yet mechanisms restricting its spatial and temporal activity remain incompletely understood. Here we identify SorCS2, a VPS10p-domain sorting receptor, as a conserved regulator of Wnt signaling homeostasis. Integrating proteomics, cell biology,...

ORGANISM(S): Mus musculus (Mouse)

2026-10-02 | PXD085067 | Pride

Wnt/β-catenin signaling Wnt5a Dopaminergic circuits Wnt homeostasis Ror2 Intracellular sorting Sorcs2 Tcf4 Wnt1 Noncanonical wnt signaling

Gene transcript alterations exhibited in luminal and basal epithelial compartments with impaired Ror2 signaling

Microarray analyses revealed distinct gene expression alterations in the luminal and basal epithelial compartments in the absence of Ror2 with marked alterations observed in genes associated with actin filament-based processes and the actin cytoskeletal network. Given that Ror2 expression resides in...

ORGANISM(S): Mus musculus

2015-01-09 | E-GEOD-57985 | biostudies-arrayexpress

Targeting breast cancer stem cells by a ROR2 specific antibody

PRJNA789897 | ENA

Role of Ror2 in primordial germ cell migration

Primordial germ cells (PGCs), the embryonic precursors of eggs and sperm, are a unique model for identifying and studying regulatory mechanisms in singly migrating cells. From their time of specification to eventual colonization of the gonad, mouse PGCs traverse through and interact with many differ...

ORGANISM(S): Mus musculus

2014-08-08 | E-GEOD-60179 | biostudies-arrayexpress

ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma (RNA-Seq)

PRJNA1066338 | ENA

Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during root development

PRJNA678015 | ENA

ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma [RNA-seq siROR2 ]

PRJNA1067699 | ENA

WNT11/ROR2 signaling is associated with tumor invasion and poor survival in breast cancer

PRJNA679736 | ENA

Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma.

Not available