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TranscriptomicsTCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions
Surprisingly few pathways signal between cells, raising questions about mechanisms for tissue-specific responses. In particular, Wnt ligands signal in many mammalian tissues, including the intestinal epithelium, where constitutive signaling causes cancer. Genome-wide analysis of DNA cis-regulatory r...
ORGANISM(S): Homo sapiens 
2010-08-11 | E-GEOD-22572 | biostudies-arrayexpress
TranscriptomicsComplex Balanced Translocation Disrupting TCF4 and Altering TCF4 Isoform Expression Segregates as Mild Autosomal Dominant Intellectual Disability
Mutations of TCF4, which encodes a basic helix-loop-helix transcription factor, cause Pitt-Hopkins syndrome (PTHS) via multiple genetic mechanisms. TCF4 is a complex locus expressing multiple transcripts by alternative splicing and use of multiple promoters. We report a three-generation family segre...
ORGANISM(S): Homo sapiens 
2016-05-31 | E-GEOD-77742 | biostudies-arrayexpress
TranscriptomicsRNA-seq of TCF4 silencing in A431 cells
TCF4 was silenced in cutaneous squamous cell carcinoma of A431 cells, and detected the mRNA profiles compared to the negative control and blank control.
ORGANISM(S): Homo sapiens 
2019-07-06 | E-MTAB-7372 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of TCF4 in human LS174AT cells using Nimblegen human genome-wide chips
genome-wide ChIP-on-chip against TCF4 in LS174T cells, performed on NimbleGen Systems, Inc. human genome-wide 38-chip, hg17 array set followed by verification using biological replicates on a dedicated design.
ORGANISM(S): Homo sapiens 
2008-02-13 | E-TABM-402 | biostudies-arrayexpress
TranscriptomicsRna-Seq expression profiling of Defa6+ cells possessing either wild-type Tcf4 or heterozygous and homozygous loss of Tcf4 protein isolated from mouse small intestinal epithelium
The T-cell factor 4 (Tcf4) protein (encoded by the Tcf7l2 gene) is a nuclear transcription regulator, which plays a key role in maintaining intestinal homeostasis, stem cell self-renewal and epithelial cell differentiation. Tcf4 has been identified as a crucial regulator of Paneth cell function in s...
ORGANISM(S): Mus musculus 
2026-05-01 | E-MTAB-13730 | biostudies-arrayexpress
TranscriptomicsSingle cell expression analysis of Defa6+ cells possessing either wild-type Tcf4 or homozygous loss of the Tcf4 protein isolated from mouse small intestinal epithelium
The T-cell factor 4 (Tcf4) protein (encoded by the Tcf7l2 gene) is a nuclear transcription regulator, which plays a key role in maintaining intestinal homeostasis, stem cell self-renewal and epithelial cell differentiation. Tcf4 has been identified as a crucial regulator of Paneth cell function in s...
ORGANISM(S): Mus musculus 
2026-06-29 | E-MTAB-14489 | biostudies-arrayexpress
GenomicsCytokine stimulated keratinocytes (TCF4 KD)
Cytokine stimulated keratinocytes (TCF4 KD)
PRJNA1082391 | ENA
GenomicsDouble fragmentation ChIP-seq provides single nucleotide resolution Tcf4 binding characteristics
ChIP-seq has become the method of choice for studying functional DNA-protein interactions on a genome wide scale. The method is based on co-immunoprecipitation of DNA binding proteins with formaldehyde cross-linked DNA, followed by deep sequencing of immunoprecipitated chromatin fragments, allowing ...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-18481 | biostudies-arrayexpress
GenomicsGenome-wide maps of TCF4 in CAL27 sphere cells
Genome-wide maps of TCF4 in CAL27 sphere cells
PRJNA1043099 | ENA
GenomicsA novel human organoid model system reveals requirement of TCF4 for 2 oligodendroglial differentiation
TCF4 in human OPC differentiation
PRJEB87238 | ENA
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