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MetabolomicsCorpora amylacea profiling reveals disease stage and brain region-specific alterations in glycogen metabolism in Alzheimer’s disease patient brains (MS (MTBLS))

Increasing evidence indicates that shifts in brain polysaccharide metabolism can influence the progression of multiple neurodegenerative diseases. Here we perform MALDI-MSI analysis of glycogen at different chain lengths in patients at different stages of Alzheimer's Disease. We look at frontal c...

2026-06-12 | MTBLS14754 | MetaboLights
MetabolomicsHuman Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically-developing (TD) and ASD individuals, though it remains unclear whether the microbiome contrib...
2019-07-04 | MTBLS726 | MetaboLights
GenomicsEvolutionary Significance of DNA Methylation in Human and Chimpanzee Brains
We compared the genome-wide patterns of DNA methylation in the brains of humans to those of our closest evolutionary relative, chimpanzees, using base-pair resolution whole-genome methylation maps of the prefrontal cortex. Our data reveal that the prefrontal cortex is the most heavily methylated am...
ORGANISM(S): Human 
2012-09-04 | E-GEOD-37202 | biostudies-arrayexpress
TranscriptomicsExpression data from post mortem Alzheimer's disease brains
To identify molecular pathological alterations in AD brains, we performed interspecies comparative microarray analyses using RNAs prepared from postmortem human brain tissues donated for the Hisayama study and hippocampal RNAs from the triple-transgenic mouse model of AD (3xTg-AD) Three-way ANOVA of...
ORGANISM(S): Homo sapiens 
2013-04-17 | E-GEOD-36980 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brains following nicotine-induced seizures
Nicotine, acting through the neuronal nicotinic acetylcholine receptors (nAChR), can induce seizures in mice. We aimed to study brain transcriptional response to seizure and to identify genes whose expression is altered after nicotine-induced seizures. Whole brains of untreated mice were compared to...
ORGANISM(S): Mus musculus 
2008-04-09 | E-GEOD-6614 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression and regulation in human, chimpanzee, and macaque brain
Among other factors, changes in gene expression on the human evolutionary lineage have been suggested to play an important role in the establishment of human-specific phenotypes. However, the molecular mechanisms underlying these expression changes are largely unknown. Here, we have explored the rol...
ORGANISM(S): Homo sapiens 
2011-10-17 | E-GEOD-26545 | biostudies-arrayexpress
TranscriptomicsA dual genetic constraint underlies the conservation of early brains in vertebrates
As the body plan, the embryonic brain bauplan reflects the shared features of vertebrate brains. Yet, disagreements among sparse histogenetic frameworks have undermined the bauplan’s power to trace homologies. Here, we generate and integrate five vertebrate single-cell multi-omic atlases of early em...
ORGANISM(S): Mus musculus 
2026-03-15 | E-MTAB-16735 | biostudies-arrayexpress
ProteomicsS-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
Here, we used a method, SNO trapping by triaryl phosphine (SNOTRAP), combined with mass spectrometry, to identify SNO-proteins present in post-mortem brain samples. Following analysis of SNO-proteins in samples of 11 human brains from patients LBD and controls, we detected 943 SNO-proteins and 1,552...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD036703 | Pride
Lbd Human brain Snotrap 
UnknownComplex mosaic structural variations in human fetal brains.
Not available
S-EPMC7706730 | biostudies-literature
GenomicsEpigenetic landscape of Human Brains by Single Nucleus Methylation Sequencing - pool0_h1930001_CBV
Epigenetic landscape of Human Brains by Single Nucleus Methylation Sequencing - pool0_h1930001_CBV
PRJNA957275 | ENA
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