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ProteomicsMetabolic bypass partially rescues S-nitrosylation-induced TCA cycle inhibition and synapse loss in Alzheimer’s disease human neurons
In Alzheimer’s disease (AD), dysfunctional mitochondrial metabolism has been associated with synaptic loss, the major pathological correlate of cognitive decline. Mechanistic insight for this relationship, however, is still lacking. Here, comparing isogenic wild-type and AD mutant human induced plur...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042436 | Pride
S-nitrosylation Alzheimer’s disease Mitochondrial metabolism Tca cycle inhibition 
ProteomicsS-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
Here, we used a method, SNO trapping by triaryl phosphine (SNOTRAP), combined with mass spectrometry, to identify SNO-proteins present in post-mortem brain samples. Following analysis of SNO-proteins in samples of 11 human brains from patients LBD and controls, we detected 943 SNO-proteins and 1,552...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD036703 | Pride
Lbd Human brain Snotrap 
ProteomicsS-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration
Protein S-nitrosation (SNO-protein) is a post-translational modification in which a cysteine (Cys) residue is modified by nitric oxide (SNO-Cys). SNO-proteins impact many biological systems, but their identification has been technically challenging. We developed a chemical proteomic strategy - SNOTR...
ORGANISM(S): Mus musculus (Mouse) 
2016-03-31 | PXD003802 | Pride
S-nitrosylation Alzheimer's disease Neurodegeneration 
UnknownS-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.
Not available
S-EPMC4839463 | biostudies-literature
UnknownMechanistic insight into female predominance in Alzheimer's disease based on aberrant protein S-nitrosylation of C3.
Not available
S-EPMC9750152 | biostudies-literature
UnknownMetabolic Bypass Rescues Aberrant S-nitrosylation-Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons.
Not available
S-EPMC10966553 | biostudies-literature
UnknownSystems Biology Reveals S-Nitrosylation-Dependent Regulation of Mitochondrial Functions in Mice with Shank3 Mutation Associated with Autism Spectrum Disorder.
Not available
S-EPMC8224296 | biostudies-literature
UnknownShank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function.
Not available
S-EPMC6614015 | biostudies-literature
ProteomicsS-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
A causal relationship between mitochondrial metabolic dysfunction and neurodegeneration has been strongly implicated in synucleinopathies, including Parkinson’s disease (PD) and Lewy body dementia (LBD), but the underlying molecular basis is not fully understood. Here, using human induced pluripoten...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD036797 | Pride
S-nitrosylation Alpha-synuclein Tca cycle Mitochondrial dysfunction 
ProteomicsArsenic induces reversible nitrosative stress and behavioural changes in mice
Studies on exposure of mice to Arsenic, combined with unique tools developed in our laboratory to determine the consequences of NO formation in mouse brain and neuronal cell culture, will probe mechanistic pathways of nitrosative damage operable in behavioural development.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD012691 | Pride
Nitric oxide Brain Autism. s-nitrosylation Snotrap Arsenic 
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