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TranscriptomicsA comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
The inactive X chromosome (Xi) serves as a model to understand gene silencing on a global scale. Here, we perform identification of direct RNA interacting proteins? (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing. We discover multiple classes of inte...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-67516 | biostudies-arrayexpress
ProteomicsSerial interactome capture of the human cell nucleus
Novel RNA-guided cellular functions are paralleled by an increasing number of RNA binding proteins (RBPs). We present “serial interactome capture” (serIC), a multiple purification procedure of UV-crosslinked poly(A)-RNA-protein complexes that enables global RBP detection with maximal specificity. We...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080265 | MassIVE
TranscriptomicsIdentification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma
LMO2 regulates gene expression facilitating the formation of multipartite DNA-binding complexes. In B cells, LMO2 is specifically up-regulated in the Germinal Center (GC) reaction and is expressed in GC-derived non-Hodgkin’s lymphomas. LMO2 is one of the most powerful prognostic indicators in DLBCL ...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-34576 | biostudies-arrayexpress
GenomicsThe SARS-CoV-2 RNA-protein interactome in infected human cells
The SARS-CoV-2 RNA-protein interactome in infected human cells
PRJNA646247 | ENA
ProteomicsAssembly of cellular proteins with the HIV-1 genome into viral particles regulate virus production and infectivity
The initial steps of the human immunodeficiency virus 1 (HIV-1) lifecycle are regulated by cellular RNA-binding proteins (RBPs). However, the scope of these early host-virus interactions remain largely uncharecterised. To fill this gap, we developed in virion RNA interactome capture (ivRIC) to profi...
ORGANISM(S): Homo sapiens (Human) HIV-1 vector pNL4-3 
2026-05-25 | PXD042829 | Pride
Hiv  rna  rna-binding protein  virus infection  virion  viral particle  rev  rna-interactome capture  pura  purb 
ProteomicsFirst identification of ITM2B interactome in the human retina
ITM2B is a type II ubiquitous transmembrane protein which role remains unclear. ITM2B mutations have been associated with different disorders: mutations leading to longer mutant proteins have been reported in two distinct Alzheimer-like autosomal dominant disorders with early-onset progressive demen...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020088 | Pride
Ap-ms Human Itm2b Retina Interactome 
UnknownMultiplexed kinase interactome profiling quantifies cellular network activity and plasticity.
Not available
S-EPMC10072906 | biostudies-literature
UnknownBioID2-Based Tau Interactome Reveals Novel and Known Protein Interactions Associated with Multiple Cellular Pathways.
Not available
S-EPMC12495503 | biostudies-literature
ProteomicsHuman 293T FLAG-ZNF408 associated complex
We employed affinity purification combined with mass spectrometry to interrogate the cellular interactome of ZNF408.
ORGANISM(S): Homo sapiens (Human) 
2024-06-26 | PXD048265 | Pride
Human 293t 
ProteomicsA human interactome in three quantitative dimensions organized by stoichiometries and abundances
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed glob...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2016-06-17 | MSV000079835 | MassIVE
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