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ProteomicsTAILS identifies candidate substrates and biomarkers of ADAMTS7, a therapeutic protease target in coronary artery disease
MacDonald BT, Keshishian H, Mundorff CC, Arduini A, Lai D, Bendinelli K, Popp NR, Bhandary B, Clauser KR, Specht H, Elowe NH, Laprise D, Xing Y, Kaushik VK, Carr SA, Ellinor PT. Loss-of-function mutations in the secreted enzyme ADAMTS7 (a disintegrin and metalloproteinase with thrombospondin motifs ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-03 | MSV000088508 | MassIVE
TranscriptomicsEffects of knockdown of ROCK1 and ZIPK on gene expression in cultured human vascular smooth muscle cells
Rho-associated kinase (ROCK) and zipper-interacting protein kinase (ZIPK) have been implicated in diverse physiological functions, including smooth muscle contraction, cell proliferation, cell adhesion, apoptosis, cell migration and inflammation. Many aspects of regulation via ROCK and ZIPK, however...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-56819 | biostudies-arrayexpress
TranscriptomicsFunctional analysis of TWIST1 domains regulating smooth muscle cell phenotype
TWIST1, a bHLH transcription factor, regulates mesenchymal specification, differentiation, proliferation and migration during development and in diseases such as cancer. More recently, genome-wide association studies have identified TWIST1 as a causal gene that increases risk for multiple vascular ...
ORGANISM(S): Homo sapiens 
2025-10-14 | E-MTAB-15722 | biostudies-arrayexpress
TranscriptomicscDNA microarray expression data from human aortic smooth muscle cells compared for 9p21.3 coronary artery disease risk locus genotypes
The 9p21.3 genetic locus is a well-established risk factor for coronary artery disease (CAD), however there is much about its exact mechanism that is yet to be established. To explore the impact of the 9p21.3 CAD risk locus on gene expression within a pathologically relevant cell type the transcript...
ORGANISM(S): Homo sapiens 
2024-02-01 | E-MTAB-12709 | biostudies-arrayexpress
ProteomicsADAMTSL4 deficiency disrupts vascular smooth muscle matricellular integrity and predisposes to spontaneous coronary artery dissection
Background: Human genetic discovery studies have implicated ADAMTSL4 as a putative susceptibility locus for spontaneous coronary artery dissection (SCAD). Although biallelic ADAMTSL4 variants cause ectopia lentis via impaired fibrillin microfibril assembly the vascular consequences of heterozygous A...
ORGANISM(S): Homo sapiens (Human) 
2026-10-06 | PXD083670 | Pride
Human coronary artery smooth muscle cells 
ProteomicsBioID2-based proximity labeling identifies DDIT4-interacting proteins in human coronary artery smooth muscle cells
DDIT4 (DNA damage-inducible transcript 4) is a stress-responsive protein that has been implicated in vascular smooth muscle cell (VSMC) phenotypic switching and vascular remodeling. However, the comprehensive protein interaction network of DDIT4 in VSMCs remains poorly characterized. In this study, ...
ORGANISM(S): Homo sapiens (Human) 
2026-10-05 | PXD083369 | Pride
Ddit4  bioid2  proximity labeling  protein-protein interactions  vascular smooth muscle cells  vsmc phenotypic switching  proteomics  biotinylation 
GenomicsTranscriptional profiling of calcifying human primary coronary artery smooth muscle cells
Transcriptional profiling of calcifying human primary coronary artery smooth muscle cells
PRJNA1200039 | ENA
TranscriptomicsMouse, pig, and human atherosclerotic lesions have common and distinct mesenchymal cell populations
The single-cell RNA-seq experiment aims to explore the cell-type composition of right coronary artery plaques to provide an overview of human-like atherosclerosis. The PCSK9 transgenic minipigs were subjected to 15 months of HFHC diet (HFHC group f, n=4; m, n=1). At the time of euthanasia, plaque pa...
ORGANISM(S): Sus scrofa 
2025-08-30 | E-MTAB-15464 | biostudies-arrayexpress
GenomicsCharacterization of TCF21 downstream target regions identifies a transcriptional network linking multiple independent coronary artery disease loci
Recent meta-analyses of genome wide association studies (GWAS) have identified approximately 150 loci that are associated with coronary artery disease (CAD). To link the causal genes in these loci to functional transcriptional networks, we have used chromatin immunoprecipitation sequencing (ChIP-Seq...
ORGANISM(S): Homo sapiens 
2015-04-12 | E-GEOD-61369 | biostudies-arrayexpress
GenomicsTranscriptional profiling of osteogenic medium calcified human primary coronary artery smooth muscle cells.
Transcriptional profiling of osteogenic medium calcified human primary coronary artery smooth muscle cells.
PRJNA871892 | ENA
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