Human islets - OmicsDI

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Unknown (1877)
Transcriptomics (862)
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Proteomics (96)
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Metabolomics (9)
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Clinical (1)

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mouse gut metagenome (3)
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Burkholderia pseudomallei K96243 (1)
Escherichia coli 8624 (1)
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Mus (1)

Organisms

Homo sapiens (316)
Mus musculus (132)
Rattus norvegicus (20)
Macaca mulatta (2)
Sus scrofa (1)
Danio rerio (1)
synthetic construct (1)

Repository

biostudies-arrayexpress (550)
ENA (527)
geo (425)
pride (66)
EGA (60)
MassIVE (18)
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jPOST (4)
iProX (3)
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GNPS (1)
MetabolomicsWorkbench (1)

Tissue

Cell culture (18)
Pancreatic islet (15)
Islet of Langerhans (12)
Pancreas (8)
Pancreatic islet cell (8)
Pancreatic islet beta cell (4)
Type B pancreatic cell (4)
Epithelial cell (3)
Fibroblast (3)
Liver (3)
Adipose tissue (2)
Alpha-TC1.6 cell (2)
Beta-TC3 cell (2)
Blood plasma (2)
Endocrine pancreas (2)
HiPSC cell (2)
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Stem cell (2)
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Blood (1)
Blood cell (1)
Blood serum (1)
Dendritic cell (1)
Exocrine pancreas (1)
HeLa cell (1)
Macrophage (1)
Muscle (1)
Pancreatic delta cell (1)
Pancreatic endocrine cell (1)
Permanent cell line cell (1)

Disease

Type 2 diabetes mellitus (10)
Type 1 diabetes mellitus (7)
Disease free (6)
Normal (4)
Maturity-onset diabetes of the young type 1 (2)
4T1 tumor-bearing (1)
Aggressive insulitis (1)
Nondiabetic (1)
Perineural invasion (1)
Low-stage neuroblastoma (1)
Pancreatic ductal adenocarcinoma (1)
Chronic pancreatitis (1)
Pancreatic cancer (1)
Pancreatic adenocarcinoma (1)
Normal (1)
Diabetes mellitus (1)
No disease (1)
Healthy donor tissue (1)
Adenocarcinoma (1)
Colorectal Neoplasms (1)
Diabetes (1)
Insulinoma (1)
Pancreatic endocrine carcinoma (1)

Technology Type

Mass Spectrometry (67)
Shotgun proteomics (27)
Bottom-up proteomics (18)
Affinity purification coupled with mass spectrometry proteomics (8)
Data-dependent acquisition (8)
Top-down proteomics (8)
Data-independent acquisition (7)
Mass spectrometry assay (5)
ILLUMINA, Illumina HiSeq 2500 (2)
Illumina HiSeq 2000 (2)
Mass spectrometry (2)
ILLUMINA, Illumina Genome Analyzer IIx, Illumina HiSeq 2500 (1)
Complete Genomics (COMPLETE_GENOMICS) (1)
ESI (1)
DiaPASEF (1)
SRM/MRM (1)
SWATH MS (1)

Instrument Platform

Illumina HiSeq 2000 (18)
Illumina HiSeq 2500 (14)
Illumina NovaSeq 6000 (13)
NextSeq 500 (9)
Illumina HiSeq 4000 (8)
Orbitrap Fusion Lumos (5)
Q Exactive (5)
LTQ Orbitrap Velos (4)
G2500A Hewlett Packard (3)
Affymetrix Fluidics Station 400 (3)
TimsTOF Pro 2 (3)
Illumina Genome Analyzer IIx (2)
Illumina Genome Analyzer II (2)
Orbitrap Eclipse (2)
Microbeads (1)
GeneChip Instrument System (1)
Affymetrix mouse gene 1.0 ST arrays (1)
Qiagen MinElute (1)
Affymetrix GeneChip Scanner 3000 (GCS3000) (1)
Agilent 2100 Bioanalyzer (1)
Illumina Genome Analyzer (1)
NanoDrop (1)
Scanning hardware (1)
Illumina (1)
Illumina HiSeq 1000 (1)
ACCRE (1)
Illumina MiSeq (1)
NextSeq 550 (1)
Illumina HiSeq 3000 (1)
- (1)

Publication Date

2014 (92)
2013 (83)
2023 (77)
2022 (68)
2024 (67)
2025 (65)
2015 (65)
2012 (65)
2016 (58)
2026 (57)
2021 (56)
2010 (55)
2019 (46)
2011 (40)
2020 (36)
2008 (32)
2018 (28)
2009 (26)
2017 (24)
2007 (17)
2006 (9)
2005 (5)
2004 (1)
2003 (1)

UNIPROT ID/AC

Q16850 (1)
Q9BQG2 (1)
B3KXN9 (1)
Q53HM1 (1)
Q4FEB3 (1)
Q9Y4K0 (1)
Q9HBF5 (1)
Q86SK9 (1)
E9KL42 (1)
Q3I5F7 (1)
P33897 (1)
Q99884 (1)
A8MU28 (1)
P35219 (1)
Q16698 (1)
Q5FC00 (1)
B2RBR4 (1)
Q8WUM9 (1)
Q15274 (1)
Q8WWX8 (1)
Q9NX14 (1)
Q9Y345 (1)
Q16635 (1)
Q9NST1 (1)
Q86YT5 (1)
Q96N66 (1)
Q53H96 (1)
Q6ZWT7 (1)
Q92604 (1)
Q9NWU1 (1)

CHEBI ID

CHEBI:3554 (1)
CHEBI:3338 (1)
CHEBI:3966 (1)
CHEBI:3312 (1)
CHEBI:3313 (1)
CHEBI:3628 (1)
CHEBI:3454 (1)
CHEBI:3544 (1)
CHEBI:4541 (1)
CHEBI:3322 (1)
CHEBI:3729 (1)
CHEBI:3420 (1)
CHEBI:3303 (1)
CHEBI:3513 (1)
CHEBI:3339 (1)
CHEBI:58235 (1)
CHEBI:3793 (1)
CHEBI:58414 (1)
CHEBI:36986 (1)
CHEBI:58052 (1)
CHEBI:57658 (1)
CHEBI:57836 (1)
CHEBI:18402 (1)
CHEBI:57880 (1)
CHEBI:58090 (1)
CHEBI:327995 (1)
CHEBI:57367 (1)
CHEBI:57390 (1)
CHEBI:42977 (1)
CHEBI:30913 (1)

Metabolite Name

Thymine (3)
Cholesterol (3)
Adenosine (3)
Synephrine (2)
O-phosphoethanolamine (2)
1,3-Diaminopropane (2)
Melezitose (2)
L-cystine (2)
1-methylhistamine (2)
Ribitol (2)
N6,N6,N6-Trimethyl-L-lysine (2)
Maslinic acid (2)
Norvaline (2)
Histidine (2)
Gly-Leu (2)
Glu-His (2)
2-aminoadipic acid (2)
Lactose (2)
EDTA (2)
Glycine (2)
Glycerol (2)
Trigonelline (2)
Uracil (2)
Betaine (2)
Thiamine (2)
Diethanolamine (2)
Folinic acid (2)
Cytarabine (2)
L-Proline (2)
Triethanolamine (2)

First Public Date

2023 (72)
2024 (64)
2025 (53)
2022 (49)
2021 (47)
2026 (46)
2014 (42)
2020 (38)
2019 (37)
2018 (19)
2017 (18)
2016 (17)
2013 (12)
2015 (11)
2012 (1)
2010 (1)

Study status

Completed (1)

Lab affiliation

Department of Clinical Science, Faculty of Medicine, University of Bergen, Norway (3)
Kubicek lab, Principal Investigator, Head of Molecular Discovery Platform, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria (3)
Charles Perkins Centre, School of Medical Sciences, University of Sydney, Sydney, Australia. (2)
Department of Clinical Science, University of Bergen, Norway (2)
Medical Bioanalytics Institute for Ophthalmic Research Eberhard-Karls University of Tuebingen (2)
Proteomics and Metabolomics Core Facility, Biomedical Research Institute, Seoul National University Hospital (2)
University of Oxford (2)
AstraZeneca (1)
B.S.R.C. “Alexander Fleming”, Vari, Athens, Greece (1)
Biological Sciences Division, Pacific Northwest National Laboratory (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht (1)
CABIMER (1)
CABIMER-University of Sevilla (1)
Catholic University of Leuven, Laboratory of Clinical and Experimental Endocrinology, Leuven, Belgium (1)
Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, North Carolina 27402, United States; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 28081, United States (1)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (1)
Department of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, Hebrew University of Jerusalem, Rehovot, Israel (1)
Department of Biochemistry, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, (1)
Department of Bioengineering, Stanford University, Stanford, CA, USA (1)
Department of Biology of the Cell Nucleus, Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic (1)
Department of Cell and Regenerative Biology Department of Chemistry Director of Mass Spectrometry Human Proteomics Program University of Wisconsin-Madison (1)
Department of Clinical Science, University of Bergen, Bergen, Norway Department of Pediatrics, Haukeland University Hospital, Bergen, Norway (1)
Department of Laboratory Medicine, Sahlgrenska academy, University of Gothenburg, Gothenburg, Sweden (1)
Department of Pathology and Immunology Bursky Center for Human Immunology and Immunotherapy Programs Washington University in St. Louis 660 S. Euclid Ave, Campus Box 8118 St. Louis, MO 63110 (1)
Department of Pharmaceutical Biosciences, Uppsala University (1)
Department of Pharmaceutical Sciences Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado (1)
Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy (1)
Director of Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark and Director of Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Germany (1)
Discovery Proteomics Laboratory, University of Oxford, UK (1)
Division of Endocrinology, Metabolism & Lipid Research, Washington University, St. Louis Department of Cell Biology & Physiology, Washington University, St. Louis (1)

IsPrivate

False (1)

Model Flag

Non Kinetic (1)

Modification

-17.026549 (1)
15.994915 (1)
42.010565 (1)
56.026215 (1)
59.036279 (1)
Not available (1)

Study type

Transcription profiling by array (352)
RNA-seq of coding RNA (91)
ChIP-seq (17)
Comparative genomic hybridization by array (14)
Unknown experiment type (9)
Methylation profiling by array (8)
RNA-seq of non coding RNA (7)
MicroRNA profiling by array (6)
DNA-seq (6)
Methylation profiling by high throughput sequencing (6)
ChIP-chip by array (4)
Transcription profiling by RT-PCR (4)
ChIP-chip by tiling array (3)
Animal - High-throughput sequencing (3)
Cell line - High-throughput sequencing (2)
Genotyping by array (2)
MicroRNA profiling by high throughput sequencing (2)
Other (2)
RNA-seq of coding RNA from single cells (2)
RNA-seq of total RNA (2)
FAIRE-seq (1)
Transcription profiling by SAGE (1)
Human - High-throughput sequencing (1)
High-throughput sequencing (1)
Bisulfite-seq (1)
ATAC-seq (1)
Proteomic profiling by array (1)
CUT&RUN (1)
Observational (1)

Release Date

2022 (193)
2021 (182)
2025 (174)
2020 (168)
2018 (155)
2014 (154)
2024 (153)
2023 (153)
2013 (141)
2015 (134)
2016 (133)
2019 (130)
2017 (124)
2012 (93)
2010 (73)
2011 (70)
2009 (58)
2008 (54)
2007 (27)
2026 (26)
2006 (14)
2005 (5)
2003 (3)
2001 (3)
2004 (2)
2002 (1)
2000 (1)
1999 (1)
1997 (1)
1996 (1)

Location

France (1)

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Identifying metabolite changes in human islets treated with Phospho-BAD mimicry and Inflammatory cytokines

Not available

ORGANISM(S): Homo sapiens

ST001953 | MetabolomicsWorkbench

Identification of HIPs in the islets of mice and non-diabetic human donors

Hybrid insulin peptides (HIPs) result from the linkage of an insulin C-peptide fragment and another peptide via a traditional peptide bond to generate a sequence that is not encoded in the genome. Here, we sought to identify HIPs naturally present in the pancreatic islets of non-obese diabetic (NOD)...

ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse)

2019-01-07 | PXD011606 | Pride

Hybrid insulin peptides (hips) Pancreatic islets

The human pancreatic islet transcriptome: impact of pro-inflammatory cytokines

We have used RNA-seq to identify transcripts, including splice variants, expressed in human islets of Langerhans under control condition or following exposure to the pro-inflammatory cytokines interleukin-1β (IL-1β) and interferon-γ (IFN-γ). A total of 29,776 transcripts were identified as expressed...

ORGANISM(S): Homo sapiens

2012-03-09 | E-GEOD-35296 | biostudies-arrayexpress

The Pdx1 Cistrome of Pancreatic Islets

We performed global location analysis of Pdx1 occupancy in mouse and human islets.

ORGANISM(S): Mus musculus

2012-05-23 | E-MTAB-1143 | biostudies-arrayexpress

DNA methylation profiling of male human pancreatic islets identifies loci for type 2 diabetes

Little is known about the contribution of the epigenome to the pathophysiology of type 2 diabetes (T2D). Here we have used genome-wide DNA methylation profiling to obtain the first comprehensive DNA methylation data set for human T2D pancreatic islets. Therefore, we analyzed the methylation profile ...

ORGANISM(S): Homo sapiens

2012-04-22 | E-GEOD-21232 | biostudies-arrayexpress

Deamidation in human islets of Langerhans

The β-cell plays a central role in the pathogenesis of T1D by neoantigen formation due to the generation of post-translational modifications, such as deamidation, being potential triggers for breaking immune tolerance. We report the detection by LC-MS/MS of 16 novel Gln and 27 novel Asn deamidations...

ORGANISM(S): Homo sapiens (Human)

2025-05-06 | PXD038758 | Pride

Human Pancreas Islets of langerhans

Epigenetic regulation of the MEG3-DLK1 microRNA cluster in human Type 2 diabetic islets

Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing β-cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs o...

ORGANISM(S): Homo sapiens

2013-11-22 | E-GEOD-51924 | biostudies-arrayexpress

Expression data from human pancreatic islets

Close to 50 genetic loci have been associated with type 2 diabetes (T2D), but they explain only 15% of the heritability. In an attempt to identify additional T2D genes, we analyzed global gene expression in human islets from 63 donors. Islets from cadaver donors (54 non-diabetic and 9 diabetic) were...

ORGANISM(S): Homo sapiens

2012-07-05 | E-GEOD-38642 | biostudies-arrayexpress

Transcription profiling of human islets after in vitro expansion.

Pancreatic islet transplantation as a cure for type 1 diabetes (T1D) cannot be scaled up due to a scarcity of human pancreas donors. In vitro expansion of beta cells from mature human pancreatic islets provides an alternative source of insulin-producing cells. The exact nature of the expanded cells ...

ORGANISM(S): Homo sapiens

2009-08-07 | E-GEOD-15543 | biostudies-arrayexpress

DIA-based Proteomic analysis of human islets with treatment of a PERK inhibitor

Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. We conducted this study to elucida...

ORGANISM(S): Homo sapiens (Human)

2026-06-29 | PXD074587 | Pride

Human Islets Dia Perk inhibitor

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