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MetabolomicsAn NMR metabolomics analysis pipeline for human neutrophil samples with limited source material
Untargeted 1H NMR metabolomics is a robust and reproducible approach to study metabolism in biological samples, providing unprecedented insight into altered cellular processes associated with human diseases. Metabolomics is increasingly used alongside other -omics techniques, such as proteomics and ...
2025-11-06 | MTBLS6220 | MetaboLights
TranscriptomicsTranscription profiling of human polymorphonuclear leukocytes (PMNs) from healthy individuals vs patients with X-linked chronic granulomatous disease
Polymorphonuclear leukocytes (PMNs) were obtained from healthy individuals (Healthy1, Healthy2, Healthy3, and Healthy4) or patients with X-linked chronic granulomatous disease (XCGD1, XCGD2, XCGD3, XCGD4, XCGD5, and XCGD6). The studies were performed in accordance with a protocol approved by the Ins...
ORGANISM(S): Homo sapiens 
2007-09-29 | E-GEOD-935 | biostudies-arrayexpress
TranscriptomicsActivity of the Bacillus anthracis 20 kDa protective antigen component
Edema factor of anthrax binds to the protective antigen (PA83) which cleaves to PA63 and PA20. The role of PA20 was examined using highthroughput gene expression analysis of human peripheral blood mononuclear cells (PBMC) exposed to PA20. Keywords: Toxicity determination PBMC obtained from differe...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12533 | biostudies-arrayexpress
TranscriptomicsEffects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study
The hypothesis was that 6 months of dietary n-3 FA supplementation to humans affected expression of genes that might be of significance for inflammatory processes and for Alzheimer´s disease. Effects on global gene expression profiles (Affymetrix Human Focus array) in human blood mononuclear leukocy...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-29680 | biostudies-arrayexpress
MetabolomicsA robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling
BACKGROUND: Neutrophils are phagocytic innate immune cells that play essential roles in host defence, but are also implicated in inflammatory diseases such as rheumatoid arthritis (RA) where they contribute to systemic inflammation and joint damage. Transcriptomic analysis of neutrophils has reveale...
2018-12-06 | MTBLS658 | MetaboLights
TranscriptomicsTranscription profiling of human blood leukocytes and T-cells
Monitoring genome-wide, cell-specific responses to human disease, although challenging, holds great promise for medicine’s future. Patients with injury severe enough to develop multiple organ dysfunction syndrome (MODS) are known to have multiple immune derangements, including T-cell apoptosis an...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5580 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in circulating leukocytes from chronically lonely individuals
Gene expression profiling was carried out on peripheral blood mononuclear cell mRNA samples collected from 93 older adults participating in the Chicago Health Aging and Social Relations Study (CHASRS). The primary research question is whether gene expression differs in participants who are chronica...
ORGANISM(S): Homo sapiens 
2011-03-16 | E-GEOD-25837 | biostudies-arrayexpress
TranscriptomicsA Novel Model of Common TLR4- and Injury induced transcriptional themes in Human Leukocytes (supported by NIH grant GM34695)
Fifteen human volunteer subjects (18-40 years of age) and 5 Trauma patients were studied. One volunteer group (saline + LPS [n = 8]) received a 12 hour infusion a second volunteer group (cortisol + LPS [n = 7]) received a 12 hour infusion of cortisol (3 µg/kg/min). After 6 hours of saline or corti...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-22278 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood CD2+ leukocytes from PATH particpants
Gene expression profiling was carried out on peripheral blood CD2+ leukocytes from 29 children with asthma. The primary research question is whether gene expression differs in individuals from high socioeconomic status environments vs low socioeconomic status environments. Experiment Overall Design...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-7894 | biostudies-arrayexpress
TranscriptomicsAge-associated DNA methylation changes within 5 years after birth in human blood leukocytes
Age-related changes in DNA methylation occurring in blood leukocytes during early childhood may reflect epigenetic maturation. We hypothesized that some of these changes involve gene networks of critical relevance in leukocyte biology and conducted a prospective study to elucidate the dynamics of DN...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-62219 | biostudies-arrayexpress
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