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ProteomicsComparative proteomics of CTS effect on human lung cancer H1975
Cryptotanshinone (CTS) is a lipophilic constituent of Salvia miltiorrhiza, with a broad-spectrum anticancer activity. We have observed that CTS enhances the efficacy of gefitinib in human lung cancer H1975 cells, yet little is known about its molecular mechanism. To explore how CTS enhances H1975 ce...
ORGANISM(S): Homo sapiens (Human) 
2022-02-23 | PXD031533 | Pride
Human lung cancer h1975 Lc-ms/ms 
TranscriptomicsHuman lung adenocarcinoma NCI-H1975 cells: parental vs cell lines resistant to the EGFR-TK inhibitor CNX-2006
Genome variation profiling of lung adenocarcinoma cells comparing untreated NCI-H1975 cells with CNX-2006-resistant untreated cells. Goal was to determine the potential mechanism of resistance to mutant EGFR-TKIs and rationally design novel strategies for the treatment of EGFR-mutant lung cancer pat...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-53234 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of non-small cell lung carcinoma cell line H1975 treated with cisplatin or BMS-69014 a novel panHER/VEGFR inhibitor
Non-small cell lung cancer (NSCLC) with activating mutations in the epidermal growth factor receptor (EGFR) responds to EGFR tyrosine kinase inhibitors such as erlotinib. However, secondary somatic EGFR mutations (e.g. T790M) confer resistance to erlotinib. BMS-690514, a novel panHER/VEGFR inhibitor...
ORGANISM(S): Homo sapiens 
2007-07-24 | E-TABM-239 | biostudies-arrayexpress
Proteomicscomparative proteomics of non-small cell lung cancer and small cell lung cancer
We aimed to identify the differences between these two subtypes of lung cancers and their differentially clinical treatment. Through functional analysis, we obtained differentially expressed proteins which might be assossciated with lung cancer treatment.
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD015270 | Pride
Lung cancer Proteomics Lc-mc/mc 
ProteomicsMechanism of TP53 and RB1 inactivation-induced neuroendocrine phenotype transformation in TKI-resistant lung adenocarcinoma
In order to study the mechanism of co-inactivation of RB1 and TP53 in the transformation of lung adenocarcinoma to small cell lung cancer, we established the NCI-H1975 cell line with RB1 knockdown.NCI-H1975 cells were cultured and infected with lentivirus expressing RB1-shRNA (n=3) or pLKO.1-shRNA (...
ORGANISM(S): Homo sapiens (Human) 
2023-08-20 | PXD042073 | Pride
Transformation Sclc Notch Tki therapy resistance Luad 
TranscriptomicsACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate
In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell survival under stresses, we performed genome-wide shRNA screens under hypoxi...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-61286 | biostudies-arrayexpress
ProteomicsSecretomes from non-small cell lung cancer cells induce endothelial plasticity through a partial endothelial-to-mesenchymal transition
The tumor microenvironment (TME) of non-small cell lung cancer (NSCLC) is highly heterogeneous and is involved in tumorigenesis and resistance to therapy. Among the cells of the TME, endothelial cells are associated with the latter processes through endothelial-to-mesenchymal transition (EndMT). Dur...
ORGANISM(S): Homo sapiens (Human) 
2025-04-24 | PXD054295 | Pride
Human Emt Dia-pasef Non-small cell Lung cancer Secretome 
ProteomicsErastin induced protein expression change in H1975 cells
H1975 cells were treated with DMSO and erastin, respectively. Protein was extracted and separated using SDS-PAGE electrophoresis. MS analysis was performed and protein was identified and quantified using Proteome Discoverer™ 1.3 software using the SEQUEST® search engine.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020205 | Pride
Erastin Ferroptosis Lung cancer 
UnknownNovel isobavachalcone derivatives induce apoptosis and necroptosis in human non-small cell lung cancer H1975 cells.
Not available
S-EPMC11721617 | biostudies-literature
ProteomicsFunctional proteomics-based investigation of the cellular response to farnesyl transferase inhibition in lung cancer (tipifarnib treatment of lung cancer cells)
The subcellular localization of proteins can be highly dynamic and regulated by post-translational modifications. Farnesylation is a lipid modification that enables anchoring of proteins to cellular membranes, and thus, spatially resolved signaling and activity. Due to the importance of farnesylatio...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD050480 | Pride
Proteomics Tipifarnib Lung cancer Human Hirief Cell line Lc-ms/ms 
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